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TranscriptomicsTranscription profiling of mouse lung following in-vivo intrapulmonary administration of LTK63, a non-toxic mutant of E. coli heat labile enterotoxin
Analysis of whole mouse lung gene expression signature induced by in-vivo intrapulmonary administration of LTK63. LTK63, a non-toxic mutant of E. coli heat labile enterotoxin (LT), is a potent and safe mucosal adjuvant, which has also been shown to confer generic protection to several respiratory pa...
ORGANISM(S): Mus musculus 
2007-10-09 | E-TABM-303 | biostudies-arrayexpress
TranscriptomicsMF59 and Pam3CSK4 boost adaptive responses to influenza subunit vaccine through an IFN type I independent mechanism of action
Analysis of whole mouse muscle and inguinal lymph node gene expression signature induced after 6h by in-vivo intramuscularly administration of MF59, alum, CpG, resiquimod (R848), Pam3CSK4 and DMSO and PBS controls. Analysis of splenocyte gene expression signature induced by the same treatments after...
ORGANISM(S): Mus musculus 
2012-02-22 | E-MTAB-942 | biostudies-arrayexpress
TranscriptomicsThe adjuvant effect of MF59 is due to the oil-in-water emulsion formulation, none of the individual components induce a comparable adjuvant effect.
Analysis of whole mouse muscle expression signature induced after 6 h by in-vivo intramuscular administration of MF59 or the individual components of MF59 (squalene oil, the surfactants Span 85 and Tween 80, either alone or in combination or the citrate buffer at the same concentrations/dose as with...
ORGANISM(S): Mus musculus 
2013-12-30 | E-MTAB-1408 | biostudies-arrayexpress
Transcriptomics4-week mouse comparative study on effect of neutralizing IL-17A, IL-17F and TNFa antibodies
Molecular profiling of effect of TNFα neutralization in contrast to anti-IL-17A or anti-IL-17F treatment for 28 days in lungs of M. tuberculosis infected C57BL/6 mice. Animals were treated once per week (starting day-1) with anti-mouse IL-17A or IL-17F antibodies (20 mg/kg i.p.), anti-mouse TNFα a...
ORGANISM(S): Mus musculus 
2016-12-02 | E-MTAB-5218 | biostudies-arrayexpress
TranscriptomicsRational Design of Small Molecules as Vaccine Adjuvants
Analysis of whole mouse muscle and inguinal lymph node gene expression signature induced after 24h by in-vivo intramuscularly administration of R848, SMIP-7.7, SMIP-7.8 and 4%DMSO controls. Analysis of whole mouse muscle and inguinal lymph node gene expression signature induced after 6h by in-vivo i...
ORGANISM(S): Mus musculus 
2015-11-02 | E-MTAB-2948 | biostudies-arrayexpress
TranscriptomicsTranscription profiling time course of mouse lung after in-vivo intrapulmonary administration of CpG.
Analysis of whole mouse lung gene expression signature induced by in-vivo intrapulmonary administration of CpG. CpG-containing oligodeoxynucleotides are potent mucosal adjuvants and effective as stand-alone treatment of respiratory infections in mice.
ORGANISM(S): Mus musculus 
2009-11-14 | E-TABM-823 | biostudies-arrayexpress
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