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TranscriptomicsSelective control of metabolism by the GCN2 eIF2 kinase pathway in Saccharomyces cerevisiae
When eukaryotic cells are deprived of amino acids, uncharged tRNAs accumulate and activate the conserved GCN2 protein kinase. We examine how yeast growth and tRNA charging or aminoacylation is affected during amino acid depletion in the presence and absence of GCN2. tRNA charging is measured using ...
ORGANISM(S): Saccharomyces cerevisiae 
2010-08-01 | E-GEOD-22452 | biostudies-arrayexpress
GenomicsGrowth Optimized Aminoacyl-tRNA Synthetase Levels Prevent Maximal tRNA Charging
Growth Optimized Aminoacyl-tRNA Synthetase Levels Prevent Maximal tRNA Charging
PRJNA593256 | ENA
ModelsMcFarland2020 - Synthetase sequestration Model:a combined translation and tRNA charging cycle
The Synthetase Sequestration Model (SSM) is a simplified translation model that considers explicitly two main steps in the process of tRNA aminoacylation: first, the tRNA is bound by the aminoacyl tRNA synthetase, and in a second step, the amino acid is attached to the tRNA. The tRNA then participat...
2020-02-05 | MODEL2001080005 | BioModels
GenomicsTarsl2 is evolved not for tRNA charging in vivo
Tarsl2 is evolved not for tRNA charging in vivo
PRJNA903163 | ENA
OtherGrowth Optimized Aminoacyl-tRNA Synthetase Levels Prevent Maximal tRNA Charging
Summary Aminoacyl-tRNA synthetases (aaRSs) serve a dual role in charging tRNAs. Their enzymatic activities both provide protein synthesis flux and reduce uncharged tRNA levels. Although uncharged tRNAs can negatively impact bacterial growth, substantial concentrations of tRNAs remain deacylated even...
ORGANISM(S): Bacillus subtilis 
2020-07-20 | GSE141389 | GEO
TranscriptomicsLeucine starvation series
These data represent the ratios of charged to total tRNA for E. coli auxotrophic strain CP78 during starvation for leucine over a time course of 32 minutes.
ORGANISM(S): Escherichia coli 
2010-05-27 | E-GEOD-2065 | biostudies-arrayexpress
ProteomicsQuantifying mistranslation from alanine tRNA anticodon variants in S. cerevisiae
Transfer RNAs (tRNAs) maintain translational fidelity through strict charging by their cognate aminoacyl-tRNA synthetase and codon:anticodon base pairing with the mRNA at the ribosome. Mistranslation occurs when an amino acid not specified by the genetic code is incorporated into a protein. Since al...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-10-02 | PXD038242 | Pride
Lc-msms Mistranslation Trna variants Yeast 
ModelsMcFarland2020 - Totally Asymmetric Simple Exclusion Process (TASEP) model describing the movement of particles (ribosomes) along a lattice (the mRNA)
A stochastic simulation of yeast translation using Total Asymmetric Simple Exclusion Principle (TASEP) principles, representing ribosomes, tRNAs, mRNAs, and a tRNA re-charging process involving aminoacyl tRNA synthetases
2020-02-05 | MODEL2001080004 | BioModels
TranscriptomicsTarsl2 is evolved not for tRNA charging in vivo
As a newly evolved duplicated gene of TARS1 (encoding cytoplasmic threonyl-tRNA synthetase), TARSL2 (TARS3) encodes a protein highly similar with TARS1 with only obvious difference in N-terminus. Albeit with tRNA charging activity in vitro and incorporated into the multiple tRNA synthetase complex (...
ORGANISM(S): Mus musculus 
2023-05-31 | GSE218318 | GEO
UnknownGrowth-Optimized Aminoacyl-tRNA Synthetase Levels Prevent Maximal tRNA Charging.
Not available
S-EPMC7484455 | biostudies-literature
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