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TranscriptomicsBiogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals
Parental dietary conditions can influence the metabolic traits of offspring. In mice, paternal consumption of low protein diet alters cholesterol and lipid metabolism of progeny. Here, we examine RNA species expressed in male reproductive tissues of mice. Protein restriction leads to altered levels ...
ORGANISM(S): Mus musculus 
2016-01-04 | E-GEOD-74537 | biostudies-arrayexpress
TranscriptomicsBiogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals (single embryo)
Parental dietary conditions can influence the metabolic traits of offspring. In mice, paternal consumption of low protein diet alters cholesterol and lipid metabolism of progeny. Here, we examine RNA species expressed in male reproductive tissues of mice. Protein restriction leads to altered levels ...
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-75765 | biostudies-arrayexpress
TranscriptomicsA growth-essential Tetrahymena Piwi protein carries tRNA fragment cargo
Argonaute/Piwi proteins associate with small RNAs that typically provide sequence specificity for RNP function in gene and genome regulation. Here we show that Twi12, a Tetrahymena Piwi protein essential for growth, is loaded with mature tRNA fragments. The tightly bound ~18-22 nt tRNA 3M-bM-^@M-^Y ...
ORGANISM(S): Tetrahymena thermophila 
2010-10-26 | E-GEOD-24916 | biostudies-arrayexpress
TranscriptomicstRNA fragment profiling in CLP1 mutant (kinase-dead) mice
Loss of CLP1 activity results in the accumulation of novel sets of small RNA fragments derived from aberrant processing of tyrosine pre-tRNA. Such tRNA fragments sensitize cells to oxidative stress-induced p53 activation and p53-dependent cell death. 2 samples, Wt and Clp1(k/k), no replicates
ORGANISM(S): Mus musculus 
2013-04-03 | E-GEOD-39275 | biostudies-arrayexpress
TranscriptomicsThe Translin-TRAX complex/C3PO is a ribonuclease in tRNA processing
The endogenous RNA substrates of Translin-TRAX complexes (also known as C3POs) and how they regulate diverse biological processes remain unknown. Here we show that Translin and TRAX do not play a significant role in RNAi in the filamentous fungus Neurospora crassa. Instead, the Neurospora C3PO compl...
ORGANISM(S): Neurospora crassa 
2012-07-30 | E-GEOD-38334 | biostudies-arrayexpress
TranscriptomicstRNA-Derived Small Non-Coding RNAs in Response to Ischemia Inhibit Angiogenesis
Ischemic injuries will lead to necrotic tissue damage, and post-ischemia angiogenesis plays critical roles in blood flow restoration and tissue recovery. Recently, several types of small RNAs have been reported to be involved in this process. In this study, we first generated a rat brain ischemic mo...
ORGANISM(S): Rattus norvegicus 
2016-03-16 | E-GEOD-70473 | biostudies-arrayexpress
TranscriptomicsIdentification of tRNA sequences in Lactococcus lactis
we report the identification and sequences of the tRNAome of industrially relevant microorganism Lactococcus lactis Three Next Generation sequencing runs annotated as S1, S2 and S3 were performed. Cells were harvested at exponential phase and tRNA was isolated. S1 and S2 were spiked with Phe-tRNAGAA...
ORGANISM(S): Lactococcus lactis subsp. cremoris MG1363 
2014-07-29 | E-GEOD-55392 | biostudies-arrayexpress
TranscriptomicsCLP1 links tRNA metabolism to progressive motor-neuron loss
CLP1 was the first mammalian RNA kinase to be identified. However, determining its in vivo function has been elusive. Here we generated kinase-dead Clp1 (Clp1K/K) mice that show a progressive loss of spinal motor neurons associated with axonal degeneration in the peripheral nerves and denervation of...
ORGANISM(S): Mus musculus 
2013-03-12 | E-GEOD-35924 | biostudies-arrayexpress
TranscriptomicsFragmentation of tRNA in Phytophthora infestans asexual life cycle stages and during host plant infection [life cycle]
Background: The oomycete Phytophthora infestans possesses active RNA silencing pathways, which presumably enable this plant pathogen to control the large numbers of transposable elements present in its 240 Mb genome. Small RNAs (sRNAs), central molecules in RNA silencing, are known to also play key ...
ORGANISM(S): Phytophthora infestans 
2014-12-12 | E-GEOD-62674 | biostudies-arrayexpress
TranscriptomicsBiogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals (smallRNA-seq)
Parental dietary conditions can influence the metabolic traits of offspring. In mice, paternal consumption of low protein diet alters cholesterol and lipid metabolism of progeny. Here, we examine RNA species expressed in male reproductive tissues of mice. Protein restriction leads to altered levels ...
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-75613 | biostudies-arrayexpress
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