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ProteomicsYeast glutamine tRNA synthetase doxycycline shut-off
During protein synthesis, charged tRNAs deliver amino acids to translating ribosomes, and are then re-charged by tRNA synthetases (aaRS). In humans, mutant aaRS cause a diversity of neurological disorders, but their molecular aetiologies are incompletely characterised. To understand system responses...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-02-12 | PXD017140 | Pride
Saccharomyces cerevisiae Silac Translation Trna synthetase depletion 
ModelsMcFarland2020 - Synthetase sequestration Model:a combined translation and tRNA charging cycle
The Synthetase Sequestration Model (SSM) is a simplified translation model that considers explicitly two main steps in the process of tRNA aminoacylation: first, the tRNA is bound by the aminoacyl tRNA synthetase, and in a second step, the amino acid is attached to the tRNA. The tRNA then participat...
2020-02-05 | MODEL2001080005 | BioModels
GenomicsTranscriptional responses to glutaminyl tRNA synthetase Gln4p depletion in Saccharomyces cerevisiae
Transcriptional responses to glutaminyl tRNA synthetase Gln4p depletion in Saccharomyces cerevisiae
PRJNA522049 | ENA
ProteomicsN-terminomics upon Arginyl-tRNA synthetase knock down
Arginine is associated with inflammation, cancer, and amino acid signaling, in part through the mTORC1 pathway. In cell-based assays and in the mouse, we found that arginine regulates nuclear levels of arginyl-tRNA synthetase (ArgRS), and that arginine depletion and inflammation reduced nuclear ArgR...
ORGANISM(S): Homo sapiens (Human) 
2023-04-14 | PXD024091 | Pride
Trna Aminoacyl-trna synthetase Splicing N-terminomics 
ProteomicsIsoleucyl-tRNA synthetase interactome analysis
Aminoacyl-tRNA synthetases (aaRSs) catalyze the ligation of each amino acid to the 3’ hydroxyl group of the cognate tRNA and thereby establish the genetic code for protein synthesis. AaRSs form a complicated network through assembly into a multi-synthetase complex (MSC), which is comprised of nine a...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD031261 | Pride
Trna synthetase Interactome Structure Lc-ms/ms 
TranscriptomicsTranscriptional responses to glutaminyl tRNA synthetase Gln4p depletion in Saccharomyces cerevisiae
A tet-off strain of Saccharomyces cerevisiae was constructed in which the GLN4 glutamine tRNA synthetase gene was placed under control of a doxycycline-regulated promoter. The transcriptional responses to Gln4p tRNA synthetase depletion were assessed by growth of the strain in the presence, or absen...
ORGANISM(S): Saccharomyces cerevisiae 
2019-04-01 | GSE126435 | GEO
UnknownAminoacyl-tRNA synthetase-interacting multifunctional protein 1/p43 controls endoplasmic reticulum retention of heat shock protein gp96: its pathological implications in lupus-like autoimmune diseases.
Not available
S-EPMC1899434 | biostudies-literature
UnknownDepletion of tryptophanyl-tRNA synthetase and tryptophan accumulation triggers p53-dependent apoptosis.
Not available
S-EPMC12824228 | biostudies-literature
UnknownIsoleucyl-tRNA synthetase depletion reveals vulnerabilities in Mycobacterium abscessus and Mycobacterium marinum.
Not available
S-EPMC12480861 | biostudies-literature
ModelsMcFarland2020 - Totally Asymmetric Simple Exclusion Process (TASEP) model describing the movement of particles (ribosomes) along a lattice (the mRNA)
A stochastic simulation of yeast translation using Total Asymmetric Simple Exclusion Principle (TASEP) principles, representing ribosomes, tRNAs, mRNAs, and a tRNA re-charging process involving aminoacyl tRNA synthetases
2020-02-05 | MODEL2001080004 | BioModels
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