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TranscriptomicsA growth-essential Tetrahymena Piwi protein carries tRNA fragment cargo
Argonaute/Piwi proteins associate with small RNAs that typically provide sequence specificity for RNP function in gene and genome regulation. Here we show that Twi12, a Tetrahymena Piwi protein essential for growth, is loaded with mature tRNA fragments. The tightly bound ~18-22 nt tRNA 3M-bM-^@M-^Y ...
ORGANISM(S): Tetrahymena thermophila 
2010-10-26 | E-GEOD-24916 | biostudies-arrayexpress
ProteomicstRNA synthetases are recruited to yeast ribosomes by rRNA expansion segment 7L but do not require association for func-tionality
Ribosomes expanded during evolution on the protein and rRNA level. The expanded regions do not change the active sites of ribosomes and thus do not alter the peptide bond formation reaction catalysed by the ribosome. To what purpose these expansions were selected is not fully understood. Here, we de...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-02-16 | PXD029751 | Pride
Aminoacyl-trna synthetases Yeast Rrna expansion segments Ribosome biology Translation regulation 
TranscriptomicstRNA fragment profiling in CLP1 mutant (kinase-dead) mice
Loss of CLP1 activity results in the accumulation of novel sets of small RNA fragments derived from aberrant processing of tyrosine pre-tRNA. Such tRNA fragments sensitize cells to oxidative stress-induced p53 activation and p53-dependent cell death. 2 samples, Wt and Clp1(k/k), no replicates
ORGANISM(S): Mus musculus 
2013-04-03 | E-GEOD-39275 | biostudies-arrayexpress
TranscriptomicsRibo-seq of HEK293T overexpressing WT and G240R GARS
Charcot-Marie-Tooth (CMT) disease can be caused by mutations in Aminoacyl-tRNA-Synthetases, including G240R mutation in Glycyl-tRNA-Synthetase (GARS). Ribo-seq generates snapshots of translating ribosomes on mRNA and therefore allows analysis of ribosome pausing mRNA. Here we performed Ribo-seq on l...
ORGANISM(S): Homo sapiens 
2021-09-14 | E-MTAB-10342 | biostudies-arrayexpress
TranscriptomicsThe Translin-TRAX complex/C3PO is a ribonuclease in tRNA processing
The endogenous RNA substrates of Translin-TRAX complexes (also known as C3POs) and how they regulate diverse biological processes remain unknown. Here we show that Translin and TRAX do not play a significant role in RNAi in the filamentous fungus Neurospora crassa. Instead, the Neurospora C3PO compl...
ORGANISM(S): Neurospora crassa 
2012-07-30 | E-GEOD-38334 | biostudies-arrayexpress
ProteomicstRNA Biogenesis and Specific Aminoacyl-tRNA Synthetases Regulate Senescence Stability Under the Control of mTOR
Oncogenes or chemotherapy treatments trigger the induction of suppressive pathways such as apoptosis or senescence. Senescence was initially defined as a definitive arrest of cell proliferation but recent results have shown that this mechanism is also associated with cancer progression and chemother...
ORGANISM(S): Homo sapiens (Human) 
2021-12-09 | PXD029535 | Pride
Chemotherapy Trna Er stress Senescence P21 Mtor 
ProteomicsMethionyl-tRNA synthetase interactome
During mRNA translation, tRNAs are charged by aminoacyl-tRNA synthetases (aaRS) and subsequently used by ribosomes. A multi-enzyme aminoacyl-tRNA synthetase complex (MSC) has long been proposed to increase protein synthesis efficiency by passing charged tRNAs directly to ribosomes. An alternative is...
ORGANISM(S): Homo sapiens (Human) 
2020-12-23 | PXD021527 | Pride
Aminoacyl-trna synthetases Multisynthethase complex 
GenomicsComprehensive characterization of mRNAs associated with yeast cytosolic aminoacyl-tRNA synthetases
Comprehensive characterization of mRNAs associated with yeast cytosolic aminoacyl-tRNA synthetases
PRJEB44410 | ENA
ModelsMcFarland2020 - Totally Asymmetric Simple Exclusion Process (TASEP) model describing the movement of particles (ribosomes) along a lattice (the mRNA)
A stochastic simulation of yeast translation using Total Asymmetric Simple Exclusion Principle (TASEP) principles, representing ribosomes, tRNAs, mRNAs, and a tRNA re-charging process involving aminoacyl tRNA synthetases
2020-02-05 | MODEL2001080004 | BioModels
ModelsMcFarland2020 - Synthetase sequestration Model:a combined translation and tRNA charging cycle
The Synthetase Sequestration Model (SSM) is a simplified translation model that considers explicitly two main steps in the process of tRNA aminoacylation: first, the tRNA is bound by the aminoacyl tRNA synthetase, and in a second step, the amino acid is attached to the tRNA. The tRNA then participat...
2020-02-05 | MODEL2001080005 | BioModels
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