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UnknownRisk factors associated with pulmonary hypertension in obesity hypoventilation syndrome.

Study objectives

Pulmonary hypertension (PH) is prevalent in obesity hypoventilation syndrome (OHS). However, there is a paucity of data assessing pathogenic factors associated with PH. Our objective is to assess risk factors that may be involved in the pathogenesis of PH in untreated OHS.
S-EPMC8974388 | biostudies-literature
UnknownCryo-EM Map Anisotropy Can Be Attenuated by Map Post-Processing and a New Method for Its Estimation.
One of the most important challenges in cryogenic electron microscopy (cryo-EM) is the substantial number of samples that exhibit preferred orientations, which leads to an uneven coverage of the projection sphere. As a result, the overall quality of the reconstructed maps can be severely affected, a...
S-EPMC11012471 | biostudies-literature
UnknownNew Carbonate-Based Materials and Study of Cytotoxic Capacity in Cancer Cells.
Calcium carbonate, one of the most commonly found biominerals produced by organisms, has shown great potential for the development of systems with biological applications due to its excellent biocompatibility, biodegradability, and simple chemical composition. Here, we focus on the synthesis of vari...
S-EPMC10055759 | biostudies-literature
UnknownGenetic ancestry and prostate cancer susceptibility SNPs in Puerto Rican and African American men.

Background

The Puerto Rican (PR) population is a racially admixed population that has a high prostate cancer (PCa) mortality rate. We hypothesized in this pilot study that West African Ancestry (WAA) was associated with PCa in this heterogeneous (PR) population.

Methods

A case/case an...
S-EPMC5495141 | biostudies-literature
TranscriptomicsAbundant Quantitative Trait Loci for CpG Methylation and Expression Across Human Brain Tissues
A fundamental challenge in the post-genome era is to understand and annotate the consequences of genetic variation, particularly within the context of human tissues. We describe a set of integrated experiments designed to investigate the effects of common genetic variability on DNA methylation, mRNA...
ORGANISM(S): Homo sapiens 
2010-04-20 | E-GEOD-15745 | biostudies-arrayexpress
UnknownA west African ancestry-associated SNP on 8q24 predicts a positive biopsy in African American men with suspected prostate cancer following PSA screening.

Background

African American (AA) men have the highest incidence and mortality rates of prostate cancer (PCa) among all racial groups in the United States. While race is a social construct, for AA men, this overlaps with west African ancestry. Many of the PCa susceptibility variants exhibit d...
S-EPMC11240849 | biostudies-literature
UnknownElectrospun Polyvinyl Alcohol/Sodium Alginate Nanocomposite Dressings Loaded with ZnO and Bioglass: Characterization, Antibacterial Activity, and Cytocompatibility
Not available
S-EPMC12388954 | biostudies-literature
UnknownInvestigation of the genetic aetiology of Lewy body diseases with and without dementia.
Up to 80% of Parkinson's disease patients develop dementia, but time to dementia varies widely from motor symptom onset. Dementia with Lewy bodies presents with clinical features similar to Parkinson's disease dementia, but cognitive impairment precedes or coincides with motor onset. It remains cont...
S-EPMC11228432 | biostudies-literature
TranscriptomicsNorth American Brain Expression Consortium: Laser capture microdissection of Cerebellar Purkinje Cells
Previous studies in bulk tissue suggest that there are abundant expression quantitative trait loci (eQTLs) in human brain. This sample series is of cerebellar Purkinje cells isolated using laser capture microdissection from human cases without neurological disease but of known genotypes. These data ...
ORGANISM(S): Homo sapiens 
2013-01-01 | E-GEOD-37205 | biostudies-arrayexpress
UnknownMulti-isotopic and morphometric evidence for the migration of farmers leading up to the Inka conquest of the southern Andes.
We present isotopic and morphometric evidence suggesting the migration of farmers in the southern Andes in the period AD 1270-1420, leading up to the Inka conquest occurring ~ AD 1400. This is based on the interdisciplinary study of human remains from archaeological cemeteries in the Andean Uspallat...
S-EPMC7712914 | biostudies-literature
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