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ProteomicsLysine acetylation of F-actin decreases tropomyosin-based inhibition of actomyosin activity
Actin was acetylated on lysine residues with acetic anhydride to determine its impaction on the contractile properties of the thin filaments including, actin's ability to undergo crossbridge cycling with myosin, actin's affinity for tropomyosin, and the impact of actin acetylation on calcium regulat...
ORGANISM(S): Oryctolagus cuniculus (Rabbit) 
2020-09-04 | PXD020732 | Pride
Lysine acetylation Myosin Actin Thin filament Tropomyosin In vitro motility 
TranscriptomicsTranscription profiling of different types of skeletal muscles from wild type and alpha tropomyosin transgenic slow mice to investigate the molecular mechanisms implicated in the mouse model of nemaline myopathy.
The aim of this study was to investigate the molecular mechanisms implicated in this mouse model of nemaline myopathy, and to further compare the molecular disease response in different skeletal muscles. For this purpose, snap frozen skeletla muscle specimens from wild type and transgenic for alpha ...
ORGANISM(S): Mus musculus 
2007-12-01 | E-GEOD-3384 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of adipose tissue from cytoskeletal tropomyosin transgenic mice
Analysis of the effect on global gene regulation in epididymal adipose tissue of overexpressing the cytoskeletal tropomyosin, Tm5NM1 to help understand the transcriptional events that lead to increased fat mass in transgenic mice. Total RNA obtained from epididymal adipose tissue for 3 month old tra...
ORGANISM(S): Mus musculus 
2015-06-21 | E-GEOD-25013 | biostudies-arrayexpress
ProteomicsProteomic analysis of tropomyosin isoforms expressed and purified from Expi293F (human) cells.
Human tropomyosin (Tpm) isoforms (Tpm1.6, Tpm1.7, Tpm2.1, Tpm3.1, Tpm3.2, Tpm4.2) and alpha-synuclein were expressed in Expi293F (human) cells as fusion proteins with a C-terminal intein + chitin binding domain tag. After purification on chitin resin, self-cleavage of the intein released the target ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-05-25 | MSV000087517 | MassIVE
GenomicsTropomyosin 1 deficiency facilitates cell state transitions and enhances hemogenic endothelial cell specification during hematopoiesis
Tropomyosin 1 deficiency facilitates cell state transitions and enhances hemogenic endothelial cell specification during hematopoiesis
PRJNA1021242 | ENA
TranscriptomicsGenome-wide analysis of adipose tissue from cytoskeletal tropomyosin transgenic mice
Analysis of the effect on global gene regulation in epididymal adipose tissue of overexpressing the cytoskeletal tropomyosin, Tm5NM1 to help understand the transcriptional events that lead to increased fat mass in transgenic mice.
ORGANISM(S): Mus musculus 
2015-06-21 | GSE25013 | GEO
TranscriptomicsTropomyosin 1 deficiency facilitates cell state transitions and enhances hemogenic endothelial cell specification during hematopoiesis
The goal of this study was to determine the developmental stage(s) and mechanisms by which Tropomyosin 1 impacts hematopoiesis.
ORGANISM(S): Homo sapiens 
2023-10-02 | GSE244112 | GEO
UnknownCurvature variation along the tropomyosin molecule.
Not available
S-EPMC2856783 | biostudies-literature
TranscriptomicsMouse Soleus Muscle Chronic Electrical Stimulation Study
Stimulation of the mouse hindlimb via the sciatic nerve was used to induce contractions for 4 hours to investigate acute muscle gene activation in a model of muscle phenotype conversion. Initial force production (1.6 + 0.1 g/g body weight) declined 45% within 10 min and was maintained for the remain...
ORGANISM(S): Mus musculus 
2010-06-01 | E-GEOD-14391 | biostudies-arrayexpress
UnknownA small molecule inhibitor of tropomyosin dissociates actin binding from tropomyosin-directed regulation of actin dynamics.
Not available
S-EPMC4726228 | biostudies-literature
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