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Purpose: To identify orthologous genes in Xenopus that are implicated in deafness and vestibular disorders in humans and to compare RNA-Seq and microarray to determine the advantages of each technology for Xenopus transcriptomic analysis. Methods: Inner ear RNA from X. laevis stages 56-58 was isolat...
ORGANISM(S): Xenopus laevis 
We implemented a functional genomics approach as a means to undertake a large-scale analysis of the Xenopus laevis inner ear transcriptome through microarray analysis. Microarray analysis uncovered genes within the X. laevis inner ear transcriptome associated with inner ear function and impairment i...
ORGANISM(S): Xenopus laevis 
The inner ear continues to grow and develop until the auditory and vestibular systems reach full maturity and all of the genes involved in this process have yet to be identified. Previous gene based analysis have primarily focused on the early developmental stages following induction and initial for...
ORGANISM(S): Xenopus laevis 
Sites of lactoylation were identified on both recominant human PHGDH and PHGDH in cellulo. For recombinant protein, sample was treated with 100 uM LGSH for 24 hours. For in cellulo, cells were transfected with PHGDH-mycDDK and treated with 50 uM MGO for lactoylLys identification.
ORGANISM(S): Homo sapiens (Human) 
2026-03-09 | PXD060533 | Pride
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