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TranscriptomicsTranscription profiling of human Hela cells infected with Trypanosoma cruzi
As Trypanosoma cruzi, the etiological agent of Chagas disease, multiplies in the cytoplasm of nucleated host cells, infection with this parasite is highly likely to affect host cells. We performed an exhaustive transcriptome analysis of T. cruzi-infected HeLa cells using an oligonucleotide microarra...
ORGANISM(S): Homo sapiens 
2008-04-08 | E-GEOD-7047 | biostudies-arrayexpress
TranscriptomicsWidespread, focal copy number variations (CNV) in Trypanosoma cruzi strains
Trypanosoma cruzi is a protozoan parasite and the etiologic agent of Chagas disease, an important public health problem in Latin America. T. cruzi is diploid, almost exclusively asexual, and displays an extraordinarily diverse population structure both genetically and phenotypically. Yet, to date ...
ORGANISM(S): Trypanosoma cruzi 
2011-08-05 | E-GEOD-23576 | biostudies-arrayexpress
TranscriptomicsExpression data from human primary fibroblasts treated with Trypanosoma cruzi-conditioned medium
The intracellular pathogen Trypanosoma cruzi secretes an activity that blocks TGF-β-dependent induction of connective tissue growth factor (CTGF/CCN2). Here, we address the mechanistic basis for T. cruzi-mediated interference of CTGF/CCN2 expression by examining host cell signaling pathways and the...
ORGANISM(S): Homo sapiens 
2011-09-08 | E-GEOD-16416 | biostudies-arrayexpress
TranscriptomicsTranscriptomic alterations in Trypanosoma cruzi-infected cardiac myocytes
Trypanosoma cruzi infection is a major cause of cardiomyopathy. Gene profiling studies of hearts from infected mice have revealed prominent changes in gene expression within many functional pathways. This variety of transcriptomic changes in infected mice raises the question of whether gene express...
ORGANISM(S): Mus musculus 
2010-05-15 | E-GEOD-17330 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of the Trypanosoma cruzi life-cycle
To generate a high quality, annotated gene expression database of T. cruzi trypomastigotes(TRP), amastigotes (AMA), epimastigotes (EPI), and metacyclic trypomastigotes (MET). The global assessment of transcript abundances in each life-cycle stage of T. cruzi will identify stage-regulated genes and p...
ORGANISM(S): Trypanosoma cruzi 
2010-05-15 | E-GEOD-14641 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Trypanosoma cruzi transfected with TcPUF6, a pumilio like protein
Functional genomic characterization of mRNAs associated with TcPUF6, a pumilio-like protein from Trypanosoma cruzi
ORGANISM(S): Trypanosoma cruzi 
2008-03-31 | E-MEXP-1355 | biostudies-arrayexpress
ProteomicsThe Trypanosoma cruzi Antigen and Epitope Atlas: fine characterization of antibody specificities in human Chagas Disease patients across human populations
These assays represent antibody-binding assays to analyze seroprevalence of antigens and epitopes at the individual level and also to perform fine epitope mapping characterizations. In this screening 392,299 peptides derived from reactive (antigenic) regions of Trypanosoma cruzi proteins were displa...
ORGANISM(S): Homo sapiens 
2022-08-20 | E-MTAB-11655 | biostudies-arrayexpress
TranscriptomicsImmediate/Early Response to Trypanosoma cruzi Infection Involves Minimal Modulation of Host Cell Transcription
Host cell infection by the intracellular pathogen, Trypanosoma cruzi, involves activation of signaling pathways, cytoskeletal reorganization, and targeted recruitment of host cell lysosomes. To determine the consequences of T. cruzi invasion on host cell gene expression, high density microarrays con...
ORGANISM(S): Homo sapiens 
2005-10-20 | E-GEOD-3476 | biostudies-arrayexpress
GenomicsTrypanosoma cruzi strain:CL Brener
A genome sequencing project from the Trypanosoma cruzi consortium
PRJNA11755 | ENA
GenomicsTrypanosoma cruzi
Trypanosoma cruzi mitochondrial DNA
PRJNA713613 | ENA
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