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MetabolomicsPolyamines regulate adaptive antitumor immunity by functional specialization of regulatory T cells

In cancer, metabolic changes and uncontrolled tumor growth alter nutrient availability, impacting antitumor immune responses. Regulatory T (Treg) cells are a subset of T cells with immunosuppressive properties that has been found to additionally possess the ability to control tissue homeostasis a...

2025-07-24 | MTBLS12633 | MetaboLights
TranscriptomicsDNA methylation comparison of ntTS, TS and ES cells
Placental abnormalities occur frequently in cloned animals. To investigate DNA methylation profile of trophoblast cell lineage of somatic cell nuclear transferred (NT) embryos, we established TS cells from blastocysts produced by NT at the blastocyst stage. Three independent TS cell lines derived fr...
ORGANISM(S): Mus musculus 
2010-05-16 | E-GEOD-17104 | biostudies-arrayexpress
ProteomicsMetabolic enhancement of developmental pausing (TS cells)
Embryonic stem (ES) cells and embryos reversibly pause via chemical mTOR inhibition. In this study, we investigate the tissue-specific response to mTORi-induced pausing in ES and trophoblast stem (TS) cells. To resolve the sequential rewiring of the proteome, we conducted a time-series proteomics ex...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-06 | PXD033798 | Pride
Pluripotency Mtor inhibition Embryonic stem cells Embryonic diapause 
MetabolomicsLoss of p53 exacerbates autoimmunity by reprogramming propionyl-CoA metabolism and epigenetics in Treg cells

Metabolic regulation is central to the tumor suppressor function of p53. Here we report that propionyl-CoA metabolic remodeling and epigenetic changes underpin p53-mediated restraint of autoimmunity through regulatory T (Treg) cells. By analyzing the human patients with autoimmune diseases, we fo...

2026-02-06 | MTBLS13473 | MetaboLights
TranscriptomicsConditional knockout of Sox2 in embryonic and trophoblast stem cells.
To compare the transcriptional networks governed by Sox2 in embryonic stem (ES) cells and trophoblast stem (TS) cells, we performed whole-genome expression analysis after tetracycline (Tet)-induced knockout of Sox2 in each cell type. A Tet-inducible Sox2 knockout ES cell line 2TS22C or its derivativ...
ORGANISM(S): Mus musculus 
2013-10-17 | E-GEOD-28451 | biostudies-arrayexpress
TranscriptomicsProfiling of p53-responsive genes in human breast cancer cells harboring endogenous ts-p53 E285K
The ts-p53 E285K protein is a rare p53 mutant with temperature-sensitive (ts) loss of function characteristics. In cancer cells, which express ts-p53 E285K intrinsically, endogenous wild type p53 activity is reconstituted by appropriate cultivation temperature (permissive condition). At non-appropri...
ORGANISM(S): Homo sapiens 
2012-12-31 | E-GEOD-35006 | biostudies-arrayexpress
TranscriptomicsEffect of Tet1-knockdown on gene expression in mouse ES cells cultured in ES and TS cell culture conditions
TET-family enzymes convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in DNA. Tet1 and Tet2 are Oct4-regulated enzymes that together sustain 5hmC in mouse embryonic stem (ES) cells. ES cells depleted of Tet1 by RNAi show diminished expression of the Nodal antagonist Lefty1, and displ...
ORGANISM(S): Mus musculus 
2011-02-07 | E-GEOD-26900 | biostudies-arrayexpress
TranscriptomicsMAP3K4/CBP Regulated H2B acetylation Controls Epithelial-Mesenchymal Transition in Trophoblast Stem Cells
Epithelial stem cells self-renew while maintaining multipotency, but the dependence of stem cell properties on maintenance of the epithelial phenotype is unclear. We previously showed that trophoblast stem (TS) cells lacking the protein kinase MAP3K4 maintain properties of both stemness and epitheli...
ORGANISM(S): Mus musculus 
2011-05-27 | E-GEOD-27883 | biostudies-arrayexpress
GenomicsSox2-regulatory networks in embryonic and trophoblast stem cells.
Sox2 is a pleiotropic transcription factor that regulates self-renewal and differentiation capacity in different types of stem cells, raising the possibility that it regulates similar transcriptional programs controlling common stemness. Embryonic stem (ES) cells and trophoblast stem (TS) cells are ...
ORGANISM(S): Mus musculus 
2013-10-17 | E-GEOD-28455 | biostudies-arrayexpress
TranscriptomicsDifferentiation time course of trophoblast stem cells
To characterized the changes in gene expression during the differentiation of TS cells. TS cells can be derived from two time point during embryogenesis, cell lines tested were from each of these time points. Keywords: time course TS cells derived from either E3.5 or E6.5 embryos were differentiate...
ORGANISM(S): Mus musculus 
2010-02-21 | E-GEOD-12985 | biostudies-arrayexpress
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