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ProteomicsLKB1 drives stasis and C/EBP-mediated reprogramming to an alveolar type II fate in lung cancer
LKB1 is among the most frequently altered tumor suppressors in lung adenocarcinoma. Inactivation of Lkb1 accelerates the growth and progression of oncogenic KRAS-driven lung tumors in mouse models. However, the molecular mechanisms by which LKB1 constrains lung tumorigenesis and whether the aggressi...
ORGANISM(S): Mus musculus (Mouse) 
2021-12-23 | PXD026738 | Pride
Lung adenocarcinoma Mouse model Lkb1 Tumor suppressor 
TranscriptomicsRNA-seq of human epithelium-only colonic and small intestinal organoids derived from intestinal resections, biopsy specimens and cryopreserved crypts
Patient-derived gastrointestinal epithelium-only organoids from the small and large intestine, also referred to as colonoids and enteroids, were generated as part of the development of an on-going organoid biobank at the Michigan Medicine Translational Tissue Modeling Laboratory (TTML) (www.UmichTTM...
ORGANISM(S): Homo sapiens 
2020-07-24 | E-MTAB-9339 | biostudies-arrayexpress
ProteomicsData Descriptor: Proteomic profiling across breast cancer cell lines and models
We performed quantitative proteomics of 60 human-derived breast cancer cell lines to a depth of ~13,000 proteins. The resulting high-throughput datasets were assessed for quality and reproducibility. We used the two omics datasets to identify and characterize the subtypes of breast cancer and showed...
ORGANISM(S): Homo sapiens (Human) 
2023-03-15 | PXD026581 | Pride
Protein expression Tmt Proteomic profiling Quantitative proteomics Breast cancer cell lines 
UnknownDecline in estimated glomerular filtration rate and subsequent risk of end-stage renal disease and mortality.
Not available
S-EPMC4172342 | biostudies-literature
UnknownAssociation of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis.
Not available
S-EPMC3993088 | biostudies-literature
UnknownPast Decline Versus Current eGFR and Subsequent Mortality Risk.
Not available
S-EPMC4978054 | biostudies-literature
UnknownAssociation of omega 3 polyunsaturated fatty acids with incident chronic kidney disease: pooled analysis of 19 cohorts.
Not available
S-EPMC9846698 | biostudies-literature
UnknownPreventing Early Renal Loss in Diabetes (PERL) Study: A Randomized Double-Blinded Trial of Allopurinol-Rationale, Design, and Baseline Data.
Not available
S-EPMC6647051 | biostudies-literature
UnknownComparison of risk prediction using the CKD-EPI equation and the MDRD study equation for estimated glomerular filtration rate.
Not available
S-EPMC3837430 | biostudies-literature
MetabolomicsMechanisms of Etomidate Addiction and Neuro-Hepatic Toxicity: Molecular Pathway Analysis Based on Multi-Omics Integration
Etomidate has been linked to addictive behaviors and neurotoxic and hepatotoxic effects. We established a mouse exposure model across graded etomidate doses and assessed reward using conditioned place preference (CPP). Proteomic and metabolomic profiling of cerebral tissue and right hepatic lobe tis...
2026-09-02 | MTBLS15525 | MetaboLights
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