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TranscriptomicsGenomic profiling of TP53 and non-TP53 Li-Fraumeni syndrome tumors reveals hits in the p53 and overlapping pathways
Li-Fraumeni syndrome (LFS) is a rare, clinically and genetically heterogeneous inherited cancer syndrome. Most cases are due to mutations in TP53. CHK2 is a minor predisposing locus; we recently mapped a third locus to 1q23. In both TP53 and non-TP53 LFS, there is evidence for risk heterogeneity ...
ORGANISM(S): Homo sapiens 
2008-07-16 | E-GEOD-8798 | biostudies-arrayexpress
TranscriptomicsTranslational regulation of Anopheles gambiae mRNAs in the midgut during Plasmodium falciparum infection
Malaria is caused by Plasmodium parasites, which are transmitted via the bites of infected Anopheline mosquitoes. Midgut invasion is a major bottleneck for Plasmodium development inside the mosquito vectors as a rapidly responding immune system recognizes ookinetes and recruits killing factors from ...
ORGANISM(S): Anopheles gambiae 
2012-09-21 | E-GEOD-38707 | biostudies-arrayexpress
UnknownThe Valsa Mali effector Vm1G-1794 protects the aggregated MdEF-Tu from autophagic degradation to promote infection in apple.
Not available
S-EPMC10262774 | biostudies-literature
TranscriptomicsExpression data from Arabidopsis thaliana root protoplast
BACKGROUND:Dynamic transcriptional regulation is critical for an organism's response to environmental signals and yet remains elusive to capture. Such transcriptional regulation is mediated by master transcription factors (TF) that control large gene regulatory networks. Recently, we described a dyn...
ORGANISM(S): Arabidopsis thaliana 
2016-02-08 | E-GEOD-69389 | biostudies-arrayexpress
TranscriptomicsA molecular signature of normal breast epithelial and stromal cells from Li-Fraumeni syndrome mutation carriers
Specific changes in gene expression during cancer initiation should enable discovery of biomarkers for risk assessment, early detection and targets for chemoprevention. It has been previously demonstrated that altered mRNA and proteome signatures of morphologically normal cells bearing a single inhe...
ORGANISM(S): Homo sapiens 
2010-10-21 | E-GEOD-23994 | biostudies-arrayexpress
GenomicsGenome wide H3K9ac and SAGA occupancy at OX growth phase and RC quiescent phase of yeast metabolic cycle
We found acetyl-CoA levels increase when cells are committed to growth. We also found 3 components of the SAGA complex, Spt7p, Sgf73p and Ada3p as well as histones are dynamically acetylated in tune with the acetyl-CoA levels. ChIP-seq study reveals SAGA and H3K9ac predominantly occupy growth genes ...
ORGANISM(S): Saccharomyces cerevisiae 
2011-05-19 | E-GEOD-28734 | biostudies-arrayexpress
UnknownMycoplasma hyopneumoniae evades complement activation by binding to factor H via elongation factor thermo unstable (EF-Tu).
Not available
S-EPMC7549910 | biostudies-literature
TranscriptomicsaCGH profiles of parental and oxaliplatin resistant colorectal cancer and ovarian cancer cell lines
Oxaliplatin resistance was induced in 2 colorectal cancer cell lines (LoVo-92, wt-p53 and LoVo-Li, functionally inactive p53) and one ovarian cancer cell line (A2780, wt-p53). Resistance was induced by weekly exposure to oxaliplatin for 4 hrs or 72 hrs with increasing concentrations for a period of ...
ORGANISM(S): Homo sapiens 
2014-03-01 | E-GEOD-20144 | biostudies-arrayexpress
TranscriptomicsModeling Familial Cancer with iPSC Approaches
In vitro modeling of human disease has recently become feasible with the adoption of induced pluripotent stem cell (iPSC) technology. Here, we established patient-derived iPSCs from an Li-Fraumeni Syndrome (LFS) family and investigated the role of mutant p53 in the development of osteosarcoma (OS). ...
ORGANISM(S): Homo sapiens 
2015-04-10 | E-GEOD-58123 | biostudies-arrayexpress
UnknownA Modified Actin (Gly65Val Substitution) Expressed in Cotton Disrupts Polymerization of Actin Filaments Leading to the Phenotype of Ligon Lintless-1 (Li1) Mutant.
Not available
S-EPMC7998759 | biostudies-literature
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