Sort   by:  
 Page size 
GenomicsGenome wide H3K9ac and SAGA occupancy at OX growth phase and RC quiescent phase of yeast metabolic cycle
We found acetyl-CoA levels increase when cells are committed to growth. We also found 3 components of the SAGA complex, Spt7p, Sgf73p and Ada3p as well as histones are dynamically acetylated in tune with the acetyl-CoA levels. ChIP-seq study reveals SAGA and H3K9ac predominantly occupy growth genes ...
ORGANISM(S): Saccharomyces cerevisiae 
2011-05-19 | E-GEOD-28734 | biostudies-arrayexpress
UnknownInhibitory Potential of Shen-Shuai-Ling Formulation on Renal Interstitial Fibrosis via Upregulation of PLZF.
Not available
S-EPMC8991406 | biostudies-literature
GenomicsGenome-wide Ifh1p occupancy at the OX growth phase and RC quiescent phase of the yeast metabolic cycle
We found ribosomal transcription factor Ifh1p is dynamically acetylated and phosphorylated in response to nutrient cues. ChIP-seq data revealed dynamic binding to ribosomal genes (RP) during the OX growth phase of the yeast metabolic cycle (YMC) when RP genes are highly induced, and weaker binding i...
ORGANISM(S): Saccharomyces cerevisiae 
2013-07-05 | E-GEOD-39147 | biostudies-arrayexpress
ProteomicsIntegrated transcriptomics and proteomics analyses reveal anthelmintic mechanism of arctigenin against Gyrodactylus kobayashii
The widespread resistance of parasitic worms to commonly used anthelmintics highlights the urgent need for development of new effective chemicals. Arctigenin (ARC) is a natural lignin compound that exhibits excellent anthelminthic efficacy against infections of Gyrodactylus, but knowledge about the ...
ORGANISM(S): Gyrodactylus kobayashii Apis mellifera (Honeybee) 
2020-05-26 | PXD010913 | Pride
Gyrodactylus arctigenin itraq Target 
GenomicsA high-resolution view of transcription and chromatin states across distinct metabolic states in budding yeast
Under continuous, glucose-limited conditions, budding yeast exhibit robust metabolic cycles associated with major oscillations of gene expression and metabolic state. However, how such fluctuations might be coordinately linked to changes in chromatin status is less well understood. Here, we examine ...
ORGANISM(S): Saccharomyces cerevisiae 
2014-08-31 | E-GEOD-52339 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse retina from an animal model of Huntingdons disease vs. Spinocerebellar ataxia (SCA) model
To elucidate the pathways involved in the SCA7 retinal degeneration, we used DNA GeneChips and compared the gene expression profiles of the mutant mice (R7E) and the control ones (R7N). We performed these experiments at the onset stage of the disease (3w) as well as on the moderate one (9w) in order...
ORGANISM(S): Mus musculus 
2009-02-07 | E-GEOD-3634 | biostudies-arrayexpress
TranscriptomicsExpression data from polarized macrophages: effect of p53
p53 is critically important in preventing oncogenesis but its role in non-cancer biology remains unclear. Macrophages exist as two subtypes (M1 and M2). Nutlin-3a (p53 activator) inhibits M2 gene expression and phenotype. p53 acts by suppressing transcription of c-Myc and thence regulates expressio...
ORGANISM(S): Mus musculus 
2015-01-01 | E-GEOD-53321 | biostudies-arrayexpress
TranscriptomicsHCT116 cells isogenic for p53 expression upon treatment with actinomycin D and nutlin-3
HCT116 wild type cells express p53. The isogenic HCT116 p53KO cells have the p53 gene knocked out. Cells were treated for 16 hours. Dosages for actinomycin D treatment was 1 nM, 10 nM, and 100 nM. Dosage for nutlin-3 was 4 uM. Keywords: dose response Measuring the gene expression profile of the is...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-12459 | biostudies-arrayexpress
UnknownEffects of Semen Ziziphi Spinosae extract and binary probiotics co-fermentation on the quality of yogurt and their underlying molecular mechanisms.
Not available
S-EPMC10864216 | biostudies-literature
TranscriptomicsExpression profile of HCT116 p53+/+ and P53-/- cells treated with Leptomycin B
HCT116 wild type cells express p53. The isogenic HCT116 p53KO cells have the p53 gene knocked out. Cells were treated for 16 hours. Dosages for leptomycin B treatment was 2 nM and 20 nM. Measuring the gene expression profile of the isogenic cell lines when the cells were treated with leptomycin B at...
ORGANISM(S): Homo sapiens 
2010-07-30 | E-GEOD-17472 | biostudies-arrayexpress
Sort   by:  
 Page size