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ProteomicsIntegrated transcriptomics and proteomics analyses reveal anthelmintic mechanism of arctigenin against Gyrodactylus kobayashii
The widespread resistance of parasitic worms to commonly used anthelmintics highlights the urgent need for development of new effective chemicals. Arctigenin (ARC) is a natural lignin compound that exhibits excellent anthelminthic efficacy against infections of Gyrodactylus, but knowledge about the ...
ORGANISM(S): Gyrodactylus kobayashii Apis mellifera (Honeybee) 
2020-05-26 | PXD010913 | Pride
Gyrodactylus arctigenin itraq Target 
ProteomicsArctigenin attenuates diabetic kidney disease through the activation of PP2A in podocytes
Arctigenin (ATG) is a major component of Fructus Arctii, which as a traditional herbal remedy reduced proteinuria in diabetic patients. However, whether ATG specifically provided renoprotection in DKD was not known. Here we report that ATG administration is sufficient to attenuate proteinuria and po...
ORGANISM(S): Homo sapiens (Human) 
2019-11-08 | PXD014976 | Pride
Actin cytoskeleton Podocytes Pp2a Drebrin-1 Arctigenin Diabetic kidney disease 
GenomicsNext Generation Sequencing Facilitates Quantitative Analysis of Macrophage (RAW264.7) with and without arctigenin treatment
Next Generation Sequencing Facilitates Quantitative Analysis of Macrophage (RAW264.7) with and without arctigenin treatment
PRJNA525768 | ENA
UnknownToxicity Study of 28-Day Subcutaneous Injection of Arctigenin in Beagle Dogs.
Not available
S-EPMC6807677 | biostudies-literature
GenomicsAnti-IgE Effect of Naturally Occurring Arctigenin on Food Allergy Association with a Distinct Transcriptome Profile
Anti-IgE Effect of Naturally Occurring Arctigenin on Food Allergy Association with a Distinct Transcriptome Profile
PRJNA759623 | ENA
Unknown28-Day Oral Chronic Toxicity Study of Arctigenin in Rats.
Not available
S-EPMC6169246 | biostudies-literature
UnknownDesign, synthesis and activity evaluation of arctigenin derivatives with HDAC inhibition activity.
Not available
S-EPMC10951978 | biostudies-literature
UnknownIdentification of phosphodiesterase-4 as the therapeutic target of arctigenin in alleviating psoriatic skin inflammation.
Not available
S-EPMC8463927 | biostudies-literature
UnknownDesign and synthesis of novel arctigenin analogues for the amelioration of metabolic disorders.
Not available
S-EPMC4416425 | biostudies-literature
UnknownArctigenin inhibits osteoclast differentiation and function by suppressing both calcineurin-dependent and osteoblastic cell-dependent NFATc1 pathways.
Not available
S-EPMC3895012 | biostudies-literature
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