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MetabolomicsATAD3A has a scaffolding role regulating mitochondria inner membrane structure and protein assembly

The ATPase Family AAA Domain Containing 3A (ATAD3A), is a mitochondrial inner membrane protein conserved in metazoans. ATAD3A has been associated with several mitochondrial functions, including nucleoid organization, cholesterol metabolism, and mitochondrial translation. To address its primary ro...

2022-01-14 | MTBLS3786 | MetaboLights
UnknownSite specific NMR characterization of abeta-40 oligomers cross seeded by abeta-42 oligomers† † Electronic supplementary information (ESI) available. See https://doi.org/10.1039/d2sc01555b
Not available
S-EPMC9337746 | biostudies-literature
ProteomicsDomain-specific p53 mutants activate EGFR by distinct mechanisms exposing tissue-independent therapeutic vulnerabilities
Mis-sense mutations affecting TP53 promote carcinogenesis both by inactivating its tumor suppressive functions, and by conferring aberrant pro-carcinogenic activities. We report here that mis-sense mutants in the p53 DNA-binding domain (DBD) and the transactivation domain (TAD) unexpectedly activate...
ORGANISM(S): Homo Sapiens (human) 
2023-02-17 | PXD031725 | JPOST Repository
ProteomicsProteomics raw data of APEC-OMV isolated from APEC (AE17) and APEC-OMV isolated from APEC infected DF-1 cells
APEC-OMV has complex proteomics. In order to screen the key virulence factors of APEC-OMV, comparative proteomics between APEC-OMV isolated from APEC and APEC-OMV isolated from APEC infection with cells was carried out, laying a good foundation for the study of the pathogenicity and pathogenic mecha...
ORGANISM(S): Escherichia Coli 
PXD029347 |
ProteomicsN Gene TurboID (Group2 +p50)
Nicotiana benthamiana plants were infiltrated with three different constructs: 1) N-TurboID-3HA 2) NTIR-TurboID-3HA or 3) Citrine-TurboID-3HA. N-TurboID is the full length N-gene fused to TurboID, NTIR-Turbo is the TIR domain of the N-gene fused to turboID, and Citrine-TurboID is the control constru...
ORGANISM(S): Nicotiana Benthamiana (ncbitaxon:4100) 
2018-10-10 | MSV000083019 | MassIVE
ProteomicsN Gene TurboID (Group1 -p50)
Nicotiana benthamiana plants were infiltrated with three different constructs: 1) N-TurboID-3HA 2) NTIR-TurboID-3HA or 3) Citrine-TurboID-3HA. N-TurboID is the full length N-gene fused to TurboID, NTIR-Turbo is the TIR domain of the N-gene fused to turboID, and Citrine-TurboID is the control constru...
ORGANISM(S): Nicotiana Benthamiana (ncbitaxon:4100) 
2018-10-10 | MSV000083018 | MassIVE
UnknownAnti-IFN-γ autoantibodies underlie disseminated Talaromyces marneffei infections.
Not available
S-EPMC7953730 | biostudies-literature
ProteomicsA compendium of RNA-binding proteins that regulate microRNA biogenesis
During microRNA-biogenesis, stem-loop structured precursors are processed in two endonucleolytic steps, giving rise to mature microRNAs (miRNAs). This process is not only regulated at the level of transcription but also posttranscriptionally by RNA-binding proteins (RBPs). Here we have used a proteo...
ORGANISM(S): Homo sapiens (Human) 
2017-04-26 | PXD004193 | Pride
Mass spectrometry Microrna Rna-protein interaction 
TranscriptomicsCasein kinase II promotes target silencing by miRISC through direct phosphorylation of the DEAD-box RNA helicase CGH-1
In this study we show that global levels of mature miRNAs are unaffected in C. elegans after knockdown of either subunit of CK2 (encoded by kin-3 and kin-10) by RNAi. Small RNAs were quantified from wild-type animals at L4 stage fed either vector (L4440), kin-3, kin-10, or alg-1 RNAi. Mature miRNA c...
ORGANISM(S): Caenorhabditis elegans 
2015-12-10 | E-GEOD-66764 | biostudies-arrayexpress
ProteomicsLncRNA LIMp27 regulates the DNA damage response through p27 in p53-defective cancer cells
P53 inactivation occurs in about 50% of human cancers, where p53-driven p21 activity is devoid and p27 becomes essential for the establishment of the G1/S checkpoint upon DNA damage. Here, we show that the E2F1-responsive lncRNA LIMp27 selectively represses p27 expression and contributes to prolifer...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000090292 | MassIVE
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