Sort   by:  
 Page size 
TranscriptomicsNovel piRNA Pathway Components Identified Among the Class of TUDOR Domain Containing Proteins
PIWI proteins and their bound piRNAs form the core of a gonad specific small RNA silencing pathway in animals that protects the genome against the deleterious activity of transposable elements. Recent studies linked the piRNA pathway to TUDOR biology, where TUDOR domains of various proteins recogniz...
ORGANISM(S): Drosophila melanogaster 
2011-08-16 | E-GEOD-30955 | biostudies-arrayexpress
TranscriptomicsTudor domain containing 12 (TDRD12) is essential for secondary piRNA biogenesis in mice
Piwi-interacting RNAs (piRNAs) are gonad-specific small RNAs that provide defence against transposable genetic elements called transposons. Our knowledge of piRNA biogenesis is sketchy, partly due to an incomplete inventory of the factors involved. Here, we identify Tudor domain-containing 12 (TDRD1...
ORGANISM(S): Mus musculus 
2013-11-04 | E-GEOD-50544 | biostudies-arrayexpress
TranscriptomicsLoss of the Mili-interacting Tdrd1 activates transposons and alters Mili-associated small RNA profile
Piwi proteins and their associated Piwi-interacting RNAs (piRNAs) are implicated in transposon silencing in the murine germline. There is currently little information on additional proteins in the murine Piwi complex and how they might regulate the entry of transcripts that accumulate as piRNAs in t...
ORGANISM(S): Mus musculus 
2009-05-24 | E-GEOD-16023 | biostudies-arrayexpress
ProteomicsTudor-based Proteomic Strategy Pan-specifically Enriches and Identifies Protein Arginine Methylation
In current study, we developed a molecular affinity strategy based on the Tudor domain of SMN, a naturally occurring methylarginine reader protein, for comprehensive proteomic profiling of cellular arginine methylation. We demonstrated that the Tudor domain-based approach exhibits broad specificity ...
ORGANISM(S): Homo sapiens (Human) 
2025-12-15 | PXD053390 | Pride
Proteomics Arginine methylation Molecular affinity-enrichment method Eif3d 
TranscriptomicsRoot transcriptome of the tsn1 tsn2 double mutant
au06-03_tsn_fj - tsn_fj - Root transcriptome of the tsn1 tsn2 double mutant - Comparison of a tsn1 tsn2 double mutant line (A10.9.3- or A13.3.11-) and an isogenic line complemented by TSN2 (A10.9.5) or TSN1 (A13.3.2) Keywords: gene knock in (transgenic),gene knock out 6 dye-swap - CATMA arrays
ORGANISM(S): Arabidopsis thaliana 
2009-04-08 | E-GEOD-15559 | biostudies-arrayexpress
GenomicsA chemical probe for Tudor domain protein SPIN1 to investigate chromatin functions
A chemical probe for Tudor domain protein SPIN1 to investigate chromatin functions
PRJNA507454 | ENA
TranscriptomicsProteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members
In germ cells, Piwi proteins interact with a specific class of small non-coding RNAs, piwi-interacting RNAs (piRNAs). Together, these form a pathway that represses transposable elements, thus safeguarding germ cell genomes. While basic models describe the operation of piRNA pathways, neither the pr...
ORGANISM(S): Mus musculus 
2009-07-25 | E-GEOD-17319 | biostudies-arrayexpress
GenomicsH3K14ac is linked to methylation of H3K9 by the Tudor domains of SETDB1
Mononucleosomes were isolated from murine ES cells and precipitated with the recombinant SETDB1 Triple Tudor Domain (3TD), recombinant SETDB1 Triple Tudor domain Y268A mutant, anti-H3K9me2 (Abcam, ab1220), or anti-H3K9me1 (Abcam, ab8896, Lot GR185298-1) antibodies.
ORGANISM(S): Mus musculus 
2018-07-30 | E-MTAB-4982 | biostudies-arrayexpress
GenomicsLoss of PHF20 does not negatively affect deposition of H4K16 acetylation, but does impact the expression of MOF targets
Protein post-translational modifications transmit signals in part by creating binding sites for effector molecules. This is especially true in epigenetic pathways where histone tails are heavily modified, resulting in the recruitment of molecules that can affect transcription. One such molecule, pla...
ORGANISM(S): Mus musculus 
2012-02-27 | E-GEOD-29306 | biostudies-arrayexpress
GenomicsTDRD3 is an effector molecule for arginine methylated histone marks
Specific sites of histone tail methylation are associated with transcriptional activity at gene loci. These methyl-marks are interpreted by effector molecules, which harbor protein domains that bind the methylated motifs and facilitate either active or inactive states of transcription. CARM1 and PRM...
ORGANISM(S): Homo sapiens 
2011-01-06 | E-GEOD-22612 | biostudies-arrayexpress
Sort   by:  
 Page size