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MetabolomicsObesogenic high-fat diet and MYC cooperate to promote lactate accumulation and tumor microenvironment remodeling in prostate cancer (Murine serum assays)

Cancer cells exhibit metabolic plasticity to meet oncogene-driven dependencies while coping with nutrient availability. A better understanding of how systemic metabolism impacts the accumulation of metabolites that reprogram the tumor microenvironment and drive cancer could facilitate development...

2024-04-10 | MTBLS3316 | MetaboLights
MetabolomicsObesogenic high-fat diet and MYC cooperate to promote lactate accumulation and tumor microenvironment remodeling in prostate cancer (Murine prostate assays)

Cancer cells exhibit metabolic plasticity to meet oncogene-driven dependencies while coping with nutrient availability. A better understanding of how systemic metabolism impacts the accumulation of metabolites that reprogram the tumor microenvironment and drive cancer could facilitate development...

2024-04-10 | MTBLS3317 | MetaboLights
ProteomicsDrosha/Dicer/miR-7/TGF-β2 axis Sustained Acidic Microenvironment-induced Lung Metastasis
Extracellular pH (pHe) is lower in many tumors than in the corresponding normal tissue. Acidic tumor microenvironment has been shown to facilitate epithelial mesenchymal transition (EMT) and tumor metastasis, while the mechanisms underlying tumor acidic microenvironment-induced tumor cell metastasis...
ORGANISM(S): Homo sapiens (Human) 
2022-04-01 | PXD016524 | Pride
Tumor acidic microenvironment  epithelial-mesenchymal transition  metastasis  microrna-7  tgf-β2 
MetabolomicsExtracellular-acidosis restricts one-carbon metabolism and preserves T cell stemness
The accumulation of acidic metabolic waste products within the tumor microenvironment profoundly inhibits effector functions of tumor-infiltrating lymphocytes (TILs). However, it is unclear whether extracellular-acidosis impacts T cell metabolic fitness and differentiation status. Here, we surprisin...
2023-01-17 | MTBLS6661 | MetaboLights
UnknownAcidic and hypoxic tumor microenvironment regulation by CaO2-loaded polydopamine nanoparticles.
Not available
S-EPMC9798656 | biostudies-literature
UnknownBRCA1 Insufficiency Induces a Hypersialylated Acidic Tumor Microenvironment That Promotes Metastasis and Immunotherapy Resistance.
Not available
S-EPMC10391349 | biostudies-literature
UnknownCircadian rhythms of macrophages are altered by the acidic pH of the tumor microenvironment.
Not available
S-EPMC10888792 | biostudies-literature
UnknownCircadian rhythms of macrophages are altered by the acidic tumor microenvironment.
Not available
S-EPMC11549407 | biostudies-literature
UnknownES-MION-Based Dual-Modality PET/MRI Probes for Acidic Tumor Microenvironment Imaging.
Not available
S-EPMC8811892 | biostudies-literature
TranscriptomicsTMPRSS2 Influences Prostate Cancer Metastasis
TMPRSS2 is an androgen-regulated cell surface serine protease expressed predominantly in prostate epithelium. TMPRSS2 is expressed highly in localized high-grade prostate cancers and in the majority of human prostate cancer metastasis. Through the generation of mouse models with a targeted deletion ...
ORGANISM(S): Mus musculus 
2014-09-09 | E-GEOD-58822 | biostudies-arrayexpress
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