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ProteomicsIdentification of tumor antigens among the HLA peptidomes of Glioblastoma tumors and plasma
Glioblastoma multiforme (GBM) is the most aggressive brain tumor with poor prognosis to most patients. Immunotherapy of GBM is a potentially beneficial treatment option, whose optimal implementation may depend on familiarity with tumor specific antigens, presented as HLA peptides by the GBM cells. F...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000084343 | MassIVE
MetabolomicsEngineered Oncolytic VSV Enhances Tumor Killing in HBV-Positive HCC
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide, with chronic hepatitis B virus (HBV) infection being a major contributor to its development. Despite this, effective treatment for HBV-associated HCC remains a significant challenge. In this study, we combined the s...
2025-07-17 | MTBLS12196 | MetaboLights
ProteomicsProteomics analysis of tumor antigens in allogenic tumor cell lysate and pancreatic tumor tissue.
Deep-proteome profiling of allogenic cell lysates and pancreatic ductal adenocarcinoma (PDAC) tissue sample with the aim to detect relevant tumor antigens (as described in Cheever et al. 2009, and directly linked to Lau et al., 2022).
ORGANISM(S): Homo sapiens (Human) 
2022-08-17 | PXD032800 | Pride
Human Mudpit Tumor antigens 
TranscriptomicsCellular Transcriptional Responses to Merkel cell polyomavirus T antigens
Merkel cell polyomavirus (MCV) is clonally integrated in over 80% of Merkel cell carcinomas and mediates tumor development through the expression of viral oncoproteins large T (LT) and small T antigens (sT). Viral integration is associated with signature mutations in the T antigen locus that result ...
ORGANISM(S): Homo sapiens 
2015-09-21 | E-GEOD-68503 | biostudies-arrayexpress
ProteomicsIdentification of tumor antigens in the HLA peptidome of patient-derived xenograft tumors in mouse
Personalized cancer immunotherapy targeting patient-specific cancer/testis (CTA) antigens and neoantigens may benefit from large-scale tumor HLA peptidome (immunopeptidome) analysis, which aims to accurately identify antigens presented by tumor cells. While significant efforts have been invested in ...
ORGANISM(S): Homo sapiens (Human) 
2020-05-27 | PXD016060 | Pride
Patient derived xenograft Tumor antigen Peptidome Hla 
MetabolomicsPharmacological Targeting of ALDH1a2 in Dendritic Cells Enhances Antigen Presentation, T Cell Activation and Anti-tumor immunity
Dendritic cell (DC) vaccines have been proposed as cancer immunotherapies due to their role as crucial antigen-presenting cells that regulate T cell functions. Despite considerable efforts to optimize ex vivo priming of DCs, DC vaccines have rarely been successful, suggesting the presence of unknown...
2025-11-03 | MTBLS10389 | MetaboLights
ProteomicsMapping the soluble human leukocyte antigen peptidome of pleural effusions reveals lung and tumor-associated antigens
Soluble HLA (sHLA) molecules released to the plasma, carry their original peptide cargo and provide insight into the protein synthesis and degradation schemes of their source cells and tissues. Other body fluids, such as pleural effusions, may also contain sHLA-peptide complexes, and can potentially...
ORGANISM(S): Homo sapiens (Human) 
2022-05-25 | PXD027766 | Pride
Tumor antigens Immunopeptisome Pleural effusion Cancer/testis antigens Hla peptidome Lung cancer Lc-ms/ms 
Proteomics,MultiomicsHLA peptides (LC-MSMS) induced by Decitabine in Glioblastoma cell lines
Treatment of cancer cells with anti-cancer drugs often fails to achieve complete remission. Yet, such drug treatments may induce alteration in the tumor’s gene expression patterns, including those of Cancer/Testis Antigens (CTA). The degradation products of such antigens can be presented as HLA pept...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080843 | MassIVE
ProteomicsUpstream open reading frames regulate proto-oncogene translation and encode HLA-presented immunogenic tumor antigens
Upstream open reading frames (uORFs) represent translational control elements within eukaryotic transcript leader sequences. Recent data showed that uORFs can encode for biologically active proteins and human leucocyte antigen (HLA)-presented peptides and suggest their potential role in cancer cell ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-06-30 | MSV000098383 | MassIVE
ProteomicsDecoding of the surfaceome and endocytome in primary glioblastoma cells identifies potential target antigens in the hypoxic tumor nicheDecoding of the surfaceome and endocytome in primary glioblastoma cells identifies potential target antigens in the hypoxic tumor niche
Immunotherapies with antibody-drug-conjugates (ADC) and CAR-T cells, targeted at tumor surface antigens (surfaceome), currently revolutionize clinical oncology. However, target identification warrants a better understanding of the surfaceome and how it is modulated by the tumor microenvironment. Her...
ORGANISM(S): Homo sapiens (Human) 
2024-05-23 | PXD048880 | Pride
Glioblastoma Tumor antigens Proteomics Hypoxia. Immunotherapy 
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