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MetabolomicsPreoperative exercise induces anti-tumor Kupffer cells to prevent surgical stress-promoted colorectal cancer liver metastasis

Kupffer cells from both Sed and PEx mice were harvested for Metabolomics. 3 weeks after tumor injection, both mice bearing MC38 tumors were sacrificed. The livers were harvested and processed into single-cell suspensions, and KCs were isolated.

2025-12-09 | MTBLS13419 | MetaboLights
MetabolomicsTFAM loss induces nuclear actin assembly upon mDia2 malonylation to promote liver cancer metastasis
The mechanisms underlying cancer metastasis remain poorly understood. Here, we report that TFAM deficiency rapidly and stably induced spontaneous lung metastasis in mice with liver cancer. Interestingly, unexpected polymerization of nuclear actin was observed in TFAM-knockdown HCC cells when cytoske...
2022-06-23 | MTBLS4307 | MetaboLights
Metabolomics1H-NMR metabolomics identifies hypoxanthine as a novel metastasis-associated metabolite
Breast cancer is one of the leading causes of death in females, mainly because of metastasis. Oncometabolites, produced via metabolic reprogramming, can influence metastatic signaling cascades. Accordingly, and based on our previous results, we hypothesized that metabolites from highly metastatic br...
2025-09-19 | MTBLS7764 | MetaboLights
MetabolomicsSingle-cell metabolic fingerprints discover a cluster of circulating tumor cells with distinct metastatic potential

Circulating tumor cells (CTCs) are recognized as direct seeds of metastasis. However, CTC count may not be the 'best' indicator of metastatic risk because their heterogeneity is generally neglected. In this study, we develop a molecular typing system to predict colorectal cancer metastasis potent...

2023-08-21 | MTBLS5028 | MetaboLights
MetabolomicsTargeting arginine metabolism reverses bone immunosuppressive microenvironment and metastasis in ARID1A-deficient triple negative breast cancer

Bone metastasis is a lethal consequence of breast cancer. AT-rich interaction domain 1A gene (ARID1A), a subunit of the switch/sucrose non-fermentable (SWI/SNF) complex, regulates immunosuppressive tumor microenvironment. ARID1A deficient triple negative breast cancer promotes bone metastasis.To ...

2026-03-24 | MTBLS12768 | MetaboLights
MetabolomicsTargeted metabolomics of pancancer brain metastasis

The molecular heterogeneity of brain metastases hampers therapeutic development for cures. To address this unmet and urgent need, we constructed a comprehensive multi-omic, single cell, and spatially resolved atlas of 1,032 pan-cancer brain metastases, identifying four robust molecular subtypes ...

2025-12-22 | MTBLS13554 | MetaboLights
TranscriptomicsGlobal analysis of metastasis-associated gene expression in the primary cultures from clinical specimens of ccRCC
Metastatic clear cell renal cell carcinoma (ccRCC) has a poor prognosis and unpredictable course and there are no molecular markers that reliably predict ccRCC metastasis. In this study, specimens from 84 patients with ccRCC were directly cultured in vitro. The primary cultures from 38 of 94 specime...
ORGANISM(S): Homo sapiens 
2008-08-27 | E-GEOD-11072 | biostudies-arrayexpress
MetabolomicsGut Microbiota Dysbiosis and Hypercholesterolemia Are Associated with Bone Metastasis in Non-Small Cell Lung Cancer
We collected baseline fecal samples from 85 patients with newly diagnosed lung cancer, 51 patients with bone metastasis (M group), and 34 patients without bone metastasis (N group). We conducted metagenomic and metabolomic sequencing to compare the differences in gut microbiota and metabolites betwe...
2026-07-10 | MTBLS15004 | MetaboLights
MetabolomicsHif1α-Dependent Uncoupling Of Glycolysis Suppresses Tumor Cell Proliferation
Hypoxia-inducible factor-1α (HIF1α) attenuates mitochondrial activity while promoting glycolysis. Paradoxically, it remains unknown why lower glycolysis is compromised in human clear cell renal cell carcinomas (ccRCC), in which HIF1α acts a tumor suppressor by inhibiting cell autonomous proliferatio...
2024-03-15 | MTBLS8901 | MetaboLights
MetabolomicsHyaluronan catabolism supports the peritoneal disseminated metastasis of cancer through the glucuronic acid pathway
When disseminated into the peritoneal cavity at the very early stage, cancer cells must adapt to the glucose- and oxygen-limited environment in peritoneal fluid, yet the key molecular regulators remain undefined. Here, we reveal that early disseminated OC cells are ingeniously utilize hyaluronic aci...
2026-07-10 | MTBLS15007 | MetaboLights
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