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MetabolomicsAzithromycin promotes relapse by disrupting immune and metabolic networks after allogeneic stem cell transplantation
Administration of azithromycin after allogeneic hematopoietic stem cell transplantation for hematological malignancies has been associated with relapse in a randomized phase 3 controlled clinical trial. Studying 240 samples from patients randomized in this trial is a unique opportunity to better und...
2022-08-22 | MTBLS406 | MetaboLights
MetabolomicsObesogenic high-fat diet and MYC cooperate to promote lactate accumulation and tumor microenvironment remodeling in prostate cancer (Murine serum assays)

Cancer cells exhibit metabolic plasticity to meet oncogene-driven dependencies while coping with nutrient availability. A better understanding of how systemic metabolism impacts the accumulation of metabolites that reprogram the tumor microenvironment and drive cancer could facilitate development...

2024-04-10 | MTBLS3316 | MetaboLights
MetabolomicsObesogenic high-fat diet and MYC cooperate to promote lactate accumulation and tumor microenvironment remodeling in prostate cancer (Murine prostate assays)

Cancer cells exhibit metabolic plasticity to meet oncogene-driven dependencies while coping with nutrient availability. A better understanding of how systemic metabolism impacts the accumulation of metabolites that reprogram the tumor microenvironment and drive cancer could facilitate development...

2024-04-10 | MTBLS3317 | MetaboLights
TranscriptomicsGene expression profile prospectively predicts peritoneal relapse after curative surgery of gastric cancer
Purpose: Our study aimed to disclose the specific gene expression profile representing peritoneal relapses inherent in primary gastric cancers and to identify patients at high risk of peritoneal relapse in a prospective study on the basis of the molecular prediction. Experimental Design: RNA samples...
ORGANISM(S): Homo sapiens 
2010-05-23 | E-GEOD-15081 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human prostate tumor samples to identify patients at risk of relapse after radical prostatectomy
We report the results of a study in which we sought to identify the patients at risk of relapse by using a transcriptomic approach and to clarify the molecular abnormalities that define tumors at risk of relapse. We used pangenomic oligoarrays (Agilent) and hybridized primary tumor with relapse vers...
ORGANISM(S): Homo sapiens 
2010-11-04 | E-MTAB-154 | biostudies-arrayexpress
ProteomicsProteomics of colorectal tumors identifies the role of CAVIN1 in tumor relapse
Colorectal cancer molecular signatures derived from omics data can be employed to stratify CRC patients and aid decisions about therapies or evaluate prognostic outcome. However, molecular biomarkers for identification of patients at increased risk of disease relapse are currently lacking. Here, we ...
ORGANISM(S): Homo sapiens (Human) 
2025-03-17 | PXD056331 | Pride
Phosphoproteomics Relapse Colorectal cancer Proteomics Cavin1 Lc-ms/ms 
TranscriptomicsCombined MYC and TP53 defects emerge at medulloblastoma relapse and define rapidly progressive, therapeutically targetable disease [gene expression]
We undertook a comprehensive clinical and biological investigation of serial medulloblastoma biopsies obtained at diagnosis and relapse. Combined MYC gene family amplifications and P53 pathway defects commonly emerged at relapse, and all patients in this molecular group died of rapidly progressive d...
ORGANISM(S): Mus musculus 
2015-04-23 | E-GEOD-62625 | biostudies-arrayexpress
TranscriptomicsComprehensive genomic analysis of relapse neuroblastoma [gene expression]
Relapse neuroblastoma were characterized by sequencing, gene expression, arrayCGH and genome-wide methylation. Here we describe the expression data. Array from tumours at relapse were compared to pretreatment tumours and corresponding normal samples.
ORGANISM(S): Homo sapiens 
2015-06-19 | E-GEOD-65303 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of relapse and no-relapse Wilms tumor
Wilms tumor (WT), the commonest renal tumor of the childhood, is originated from pluripotent metanephric blastemal cells resulting in tumors with triphasic histology, composed by blastemal, epithelial, and stromal cells. Histological subtype and tumor stage have long been recognized as important pro...
ORGANISM(S): Homo sapiens 
2011-06-01 | E-GEOD-22696 | biostudies-arrayexpress
GenomicsOncogene inactivation induced senescence facilitates tumor relapse
Oncogene inactivation induced senescence facilitates tumor relapse
PRJEB78692 | ENA
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