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TranscriptomicsTranscription profiling of human ovarian cancer cell lines grown as multicellular spheroids and treated with three chemotherapy drugs
Gene expression profiling of ovarian cancer spheroids upon treatment with three chemotherapy drugs
ORGANISM(S): Homo sapiens 
2008-05-06 | E-MEXP-1319 | biostudies-arrayexpress
TranscriptomicsGenomic characterization of ovarian cancer spheroids
Spheroids are 3D multi-cell aggregates formed in non-addherent culture conditions. In ovarian cancer (OC), they serve as a vehicle for cancer cell dissemination in the peritoneal cavity. We investigated genes and networks upregulated in three dimensional (3D) versus two-dimensional (2D) culture cond...
ORGANISM(S): Homo sapiens 
2014-01-03 | E-GEOD-53759 | biostudies-arrayexpress
ProteomicsComparison of monoculture to coculture colon cancer cell-line generated spheroids
Chromatogram library generated of pooled sample. Coculture spheroids formed from fibroblast and colon cancer cell lines, and monoculture spheroids formed from the colon cancer cell line HCT116.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-11-13 | MSV000093395 | MassIVE
TranscriptomicsCooperative blockade of CK2 and ATM kinases drives apoptosis in VHL-deficient renal carcinoma cells / RNA-seq (BRB-seq) of treated 786-O spheroids
Multicellular Tumor Spheroids (MCTS) were pre-formed for 3 days with 786-O cell line to better mimic the tumor microenviroenment. These spheroids were treated with either vehicle (DMSO), drugs alone (KU-60019 10 μM; CX-4945 5 μM) or in combination (KU + CX) for 48h before RNA extraction.
ORGANISM(S): Homo sapiens 
2021-02-04 | E-MTAB-9977 | biostudies-arrayexpress
ProteomicsMesenchymal stem cell-derived exosomes reprogram chemosensitivity pathways in cervical cancer spheroids
Cervical cancer (CC) remains a global health challenge, with chemotherapy resistance and tumor recurrence limiting treatment success. Our study investigated the effects of mesenchymal stem cell-derived exosome (MSC-Exos) pretreatment on chemotherapy sensitivity in 3D spheroids generated from HeLa an...
ORGANISM(S): Homo Sapiens (human) 
2026-04-10 | PXD069108 | JPOST Repository
TranscriptomicsChanges in Global Gene Expression Associated with 3D Structure of Tumors: an ex vivo Matrix-Free Mesothelioma Spheroid Model
Tumor microenvironments present significant barriers to anti-tumor agents. Molecules involved in multicellular tumor microenvironments, however, are difficult to study ex vivo. Here, we generated a matrix-free tumor spheroid model using the NCI-H226 mesothelioma cell line and compared the gene expre...
ORGANISM(S): Homo sapiens 
2012-06-20 | E-GEOD-37629 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human foreskin fibroblasts grown as multicellular spheroids or as a monolayer
Human foreskin fibroblasts grown as multicellular spheroids or as a monolayer
ORGANISM(S): Homo sapiens 
2009-12-30 | E-MEXP-1226 | biostudies-arrayexpress
TranscriptomicsMulticellular spheroids treated with the compound VLX600
Microarray based mRNA profiling was used to charactarize the response to the compound VLX600 in cells grown as spheroids. Cells used was colon cancer cells HCT116 and HCT116HIF1a knock-out. We identify the small molecule VLX600 as a drug that is preferentially active against quiescent cells in colon...
ORGANISM(S): Homo sapiens 
2014-02-17 | E-GEOD-53777 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by microarray of A549 cells and Ext1 knock out or wild type mouse embryonic fibroblast cells co-cultured as spheroids
Determine differentially expressed human genes in A549 tumors when co-cultured in spheroids with mouse fibroblast harbouring a mutation in the heparan sulphate elongation enzyme Ext1 compared to corresponding wild-type fibroblast/A549-containing spheroids.
ORGANISM(S): Homo sapiens 
2018-04-04 | E-MTAB-5874 | biostudies-arrayexpress
ProteomicsEnhancing therapeutic efficacy through degradation of endogenous extracellular matrix in primary breast tumor spheroids.
Cancer remains the leading cause of death globally, with nearly 20 million new cases and 10 million fatalities in 2022. The majority (90%) are solid tumors, which are strongly influenced by the tumor microenvironment (TME)—a complex network of blood vessels, connective tissues, immune cells, and the...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-07-14 | PXD061082 | Pride
Collagen 3d spheroids Breast cancer Extracellular matrix (ecm) Drug penetration Tumor microenvironment (tme) 
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