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MetabolomicsSingle-cell and spatial multi-omics reveal a recurrent multicellular niche at the tumor-stroma interface in multidrug resistance
Multi-drug resistance (MDR) is an almost inevitable end point of cancer therapy, driving rapid tumor progression, yet its evolutionary logic remains unclear because MDR tumors are rarely resected. Using paired therapy-naive and MDR melanoma specimens from a clinical trial, integrated with single-cel...
2027-08-13 | MTBLS15322 | MetaboLights
TranscriptomicsGene expression profiling of tumor stroma in human intrahepatic cholangiocarcinoma
Intrahepatic cholangiocarcinoma (ICC) is the second most common type of primary cancer in the liver. ICC is an aggressive cancer with poor prognosis and limited therapeutic strategies. The identification of new drug targets and prognostic biomarkers is an important clinical challenge for ICC. The pr...
ORGANISM(S): Homo sapiens 
2013-06-21 | E-GEOD-45001 | biostudies-arrayexpress
ProteomicsProteoMixture: A Cell Deconvolution Tool for Bulk Tissue Proteomics Data
Numerous multi-omic investigations of cancer tissue have documented varying and poor pairwise transcript:protein quantitative correlations and most deconvolution tools aiming to predict cell type proportions (cell admixture) have been developed and credentialed using transcript-level data alone. To ...
ORGANISM(S): Homo sapiens (Human) 
2024-01-12 | PXD044157 | Pride
Laser microdissection High grade serous ovarian cancer Proteomics Stroma signature Immune signature Cellular admixture Tumor signature 
TranscriptomicsComparison of primary neuroblastoma tumors and derivative early-passage cell lines using genome-wide SNP array analysis
Stromal contamination is one of the major confounding factors in the analysis of primary solid tumor samples by single nucleotide polymorphism (SNP) arrays. As we propose to employ genome-wide SNP microarray analysis as a diagnostic platform for neuroblastoma, the sensitivity, specificity, and accur...
ORGANISM(S): Homo sapiens 
2009-01-31 | E-GEOD-14656 | biostudies-arrayexpress
TranscriptomicsIL-33 activates tumor stroma to promote intestinal polyposis
Tumor epithelial cells develop within a microenvironment consisting of extracellular matrix, growth factors, and cytokines produced by non-epithelial stromal cells. In response to paracrine signals from tumor epithelia, stromal cells modify the microenvironment to promote tumor growth and metastasis...
ORGANISM(S): Homo sapiens 
2015-04-29 | E-GEOD-62518 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD90+ stromal fibromuscular cells from tumor specimens reveals down-regulation in prostate tumor-associated stromal cells involves organ-specific genes
The prostate stroma is a key mediator of epithelial differentiation and development, and potentially plays a role in the initiation and progression of prostate cancer. Isolation and characterization of viable populations of the constituent cell types of prostate tumors could provide valuable insight...
ORGANISM(S): Homo sapiens 
2009-09-18 | E-GEOD-17906 | biostudies-arrayexpress
TranscriptomicsTranslating transcriptome of cancer cells in situ in mesenchymal-rich tumor microenvironment
A mesenchymal rich stroma such as cancer-associated fibroblasts (CAFs) in breast tumors favors the selection of cancer clones with enhanced bone metastatic ability. To determine the cancer cell transcriptomic response to the mesenchymal stroma, we supplemented experimental mammary tumours with or wi...
ORGANISM(S): Homo sapiens 
2013-11-01 | E-GEOD-43306 | biostudies-arrayexpress
TranscriptomicsA tumor-stroma interaction study
A study on a newly developed tumor model to elucidated molecular changes in the stroma versus the tumor compartment by hyperbaric oxygen (HBO) treatment
ORGANISM(S): Mus musculus 
2011-06-01 | E-TABM-1103 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human tumor microenvironment during breast cancer progression
To better understand the role of tumor microenvironment in breast cancer progression, we combined laser capture microdissection and microarray analysis to provide a comprehensive catalog of gene expression changes in both tumor and tumor-associated stroma. Experiment Overall Design: We used LCM to i...
ORGANISM(S): Homo sapiens 
2009-02-26 | E-GEOD-14548 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of reactive stroma in prostate cancer
This is an analysis of stroma from 17 Grade 3 reactive stroma prostate cancer tissues and matched normal peripheral zone tissues. Keywords: two group comparison Laser capture microdissection and expression array analysis of stroma from 17 Grade 3 reactive stroma prostate cancer tissues and matched ...
ORGANISM(S): Homo sapiens 
2009-06-01 | E-GEOD-11682 | biostudies-arrayexpress
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