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TranscriptomicsMolecular control of myeloid suppressors by death pathways
The goal of this study was to evaluate the mechanisms distinguishing the different forms of myeloid suppressors in cancer and inflammation, and their indivdual roles in T cell suppression We used microarrays to profile the expression profile of myeloid suppressor cells in mouse and human samples. Th...
ORGANISM(S): Homo sapiens 
2015-04-28 | E-GEOD-61479 | biostudies-arrayexpress
TranscriptomicsFeedback Circuit among INK4 Tumor Suppressors Constrains Human Glioblastoma Development
We have developed a nonheuristic genome topography scan (GTS) algorithm to characterize the patterns of genomic alterations in human glioblastoma (GBM), identifying frequent p18INK4C and p16INK4A codeletion. Functional reconstitution of p18INK4C in GBM cells null for both p16INK4A and p18INK4C resul...
ORGANISM(S): Homo sapiens 
2008-04-29 | E-GEOD-9200 | biostudies-arrayexpress
TranscriptomicsFoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis.
Activated phosphoinositide 3-kinase (PI3K)-AKT signaling appears to be an obligate event in the development of cancer. The highly related members of the mammalian FoxO transcription factor family, FoxO1, FoxO3, and FoxO4, represent one of several effector arms of PI3K-AKT signaling, prompting geneti...
ORGANISM(S): Mus musculus 
2011-03-16 | E-GEOD-27932 | biostudies-arrayexpress
GenomicsBroad H3K4me3 Reveals Increased Transcription Elongation and Enhancer Activity at Tumor Suppressors
Tumor suppressors are mostly defined by inactivating somatic mutations in tumors, yet little is known about their epigenetic features in normal cells. Here, through integrative analysis of 1,134 genome-wide epigenetic profiles and mutations from >8,200 tumor-normal pairs, we discovered broad H3K4me3...
ORGANISM(S): Homo sapiens 
2015-07-29 | E-GEOD-67471 | biostudies-arrayexpress
UnknownMitochondrial Tumor Suppressors-The Energetic Enemies of Tumor Progression.
Not available
S-EPMC9397617 | biostudies-literature
ProteomicsReflux of Endoplasmic Reticulum proteins to the cytosol yields inactivation of tumor suppressors
In the past decades many studies reported the presence of Endoplasmic Reticulum (ER) resident proteins in the cytosol. However the mechanisms by which these proteins relocate and whether they exert cytosolic functions remain unknown. We found that select ER luminal proteins accumulate in the cytosol...
ORGANISM(S): Homo sapiens (Human) 
2021-05-03 | PXD023567 | Pride
Tumor cells Upr Endoplasmic reticulum 
TranscriptomicsTranscription profiling of mouse stratified epithelial spontaneous SCC induced by the somatic inactivation of Rb1 and Trp53 tumor suppressors
The squamous cell carcinomas represent the aggressive type of non melanoma skin cancer, the most frequent malignancy among human population. We have studied here the possible relationship between these two pathways in skin using epidermal-specific mutant mice. Loss of p53, but not pRb, produces spon...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9144 | biostudies-arrayexpress
GenomicsLow RNA stability signifies strong expression regulatability of tumor suppressors
Low RNA stability signifies strong expression regulatability of tumor suppressors
PRJNA810700 | ENA
UnknownTumor suppressors status in cancer cell line Encyclopedia.
Not available
S-EPMC3729735 | biostudies-literature
UnknownContext matters - Daxx and Atrx are not robust tumor suppressors in the murine endocrine pancreas.
Not available
S-EPMC9438929 | biostudies-literature
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