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TranscriptomicsA platform of patient-derived tumor xenografts (EOC-xenografts) to recapitulate the clinicopathology and genetic alterations of ovarian cancer
Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy. On the basis of its histopathology and molecular-genomic changes ovarian cancer has been divided into subtypes, each with distinct biology and outcome. The aim of this study was to develop a panel of patient-derived EOC-xen...
ORGANISM(S): Homo sapiens 
2015-01-07 | E-GEOD-56920 | biostudies-arrayexpress
ProteomicsQuantitative tyrosine phosphoproteomics of wild type and PTPRK KO tumour xenografts
TMT-based quantitation of tyrosine phosphoproteomes of wild type and PTPRK KO tumour xenografts to determine additional mechanisms of tumour suppression by receptor tyrosine phosphatase PTPRK
ORGANISM(S): Homo sapiens (Human) 
2024-07-03 | PXD050617 | Pride
Tmt Phosphatase Ptprk Tyrosine phosphoproteomics Tumour xenografts 
ProteomicsA mouse SWATH-MS reference spectral library enables deconvolution of species-specific proteomic alterations in human tumour xenografts
SWATH-MS enables accurate and reproducible label-free quantification of proteomes including in extensively studied model organisms such as the mouse. Here we present a comprehensive mouse reference spectral library (MouseRefSWATH) that allows quantification of up to 10,597 proteins (62.2% of mouse p...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-06-23 | PXD017209 | Pride
Swath-ms  breast cancer  dcis  mouse  human  xenograft model 
TranscriptomicsAffymetrix SNP array data for Ovarian Cancer Samples
This study aimed to generate a new panel of comprehensively, genomically characterized high-grade serous ovarian carcinoma (HGSOC) cell line and xenograft models. Multidimensional genomic data were generated and compared between cell lines/xenografts and the tumours they were derived from, indicatin...
ORGANISM(S): Homo sapiens 
2016-08-11 | E-GEOD-71522 | biostudies-arrayexpress
MetabolomicsCharacterizing ex vivo models for studying lipid metabolism in triple negative breast cancer

Lipid metabolism drives cancer progression but is difficult to model using conventional methods. In vivo models provide circulating lipids, but are costly and low throughput, while in vitro models lack sufficient lipid availability in culture media. Here, we evaluate the chick chorioallantoic mem...

2026-07-16 | MTBLS13377 | MetaboLights
TranscriptomicsTranscription profiling of human primarylung cancer tumors and their SCID mouse xenografts
MicroRNA expression in eight human non-small cell lung carcinoma xenografts grown in SCID mice was compared with the primary human tumors. Formalin-fixed and paraffin-embedded tissue specimens were used.
ORGANISM(S): Homo sapiens 
2009-06-30 | E-TABM-720 | biostudies-arrayexpress
TranscriptomicsRNASeq profiling of AZD8186-treated HCC70 xenografts
HCC70 xenografts treated with 11 doses of AZD8186 (100mg/kg BID) were compared to DMSO-treated control xenografts
ORGANISM(S): Homo sapiens 
2017-11-01 | E-MTAB-4656 | biostudies-arrayexpress
GenomicsGene expression analysis of tumour xenografts after injection of breast cancer cells treated with axolotl oocyte extracts
Gene expression analysis of tumour xenografts after injection of breast cancer cells treated with axolotl oocyte extracts
PRJNA412505 | ENA
TranscriptomicsSNP profiling of pancreatic adenocarcinoma (PDAC) xenografts
Pancreatic adenocarcinoma (PDAC) is one of the most lethal human malignancies and a major health problem. Patient-derived xenografts (PDX) are appearing as a prime approach for preclinical studies despite being insufficiently characterized as a model of the human disease and its diversity. We genera...
ORGANISM(S): Homo sapiens 
2017-12-12 | E-MTAB-5006 | biostudies-arrayexpress
ProteomicsIntegrated bottom-up and top-down proteomics of patient-derived breast tumor xenografts

Ntai, I., LeDuc, R.D., Fellers, R.T., et al., (2015) Molecular and Cellular Proteomics, Manuscript M114.047480

Bottom-up proteomics relies on the use of proteases and is the method ...

ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2019-08-28 | MSV000084247 | MassIVE
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