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Total RNA was extracted from FFPE samples of 139 chemotherapy-naïve hormone-receptor-negative breast cancers pooled from three sample sources and assayed for the expression of 21 genes within two previously reported microarray-derived prognostic signatures in 6 RT-PCR multiplexes. RT-PCR gene expre...
ORGANISM(S): Homo sapiens 
Purpose: A number of microarray studies have reported distinct molecular profiles of breast cancers (BC): basal-like, ErbB2-like and two to three luminal-like subtypes. These were associated with different clinical outcomes. However, although the basal and the ErbB2 subtypes are repeatedly recognize...
ORGANISM(S): Homo sapiens 
A conditional and isogenic system for APOBEC3B (A3B) induction in T-REx-293 cells. Cells were engineered to express doxycycline-inducible A3B-eGFP or eGFP constructs and subjected to 10 rounds of A3B-eGFP exposure causing 80-90% cell death. Control pools (eGFP) were subjected to parallel rounds of n...
ORGANISM(S): Homo sapiens 
To gain insights into the transcriptional differences between subgroups of grade III invasive ductal breast cancers, we performed gene expression profiling of a series of RNA extracted from microdissected frozen tissue from patients with breast cancer
ORGANISM(S): Homo sapiens 
Background: This study focuses on the analysis of miRNAs expression data in a cohort of 181 well characterised breast cancer samples composed primarily of triple-negative (ER/PR/HER2-negative) tumours with associated genome-wide DNA and mRNA data, extensive patient follow-up and pathological informa...
ORGANISM(S): Homo sapiens 
A comprehensive characterisation and analysis of human breast cancers through whole-genome sequencing.
A comprehensive characterisation and analysis of 560 human breast cancers through genome-wide approaches including genomics, transcriptomics and epigenomics.
Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells
Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells
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