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ProteomicsTumor microenvironment remodeling by cancer cell-released tracks on type I collagen
Metastasis is the leading cause of cancer-related deaths. During this process, tumor cells acquire invasive and migratory capacities in order to invade the surrounding tissues. To achieve this, the tumor microenvironment is altered to facilitate cancer cells proliferation and dissemination. Multiple...
ORGANISM(S): Homo sapiens (Human) 
2026-02-24 | PXD035152 | Pride
Extracellular vesicles Type i collagen fibers Migration 
TranscriptomicsGenome-wide analysis of control and MMP-14 (MT1-MMP) expressing MCF-7 cells growing in three-dimensional (3D) type I collagen gels versus monolayer cell culture conditions
In order to investigate the impact of MMP-14 (MT1-MMP) and three-dimensional (3D) culture conditions on the transcriptomes of a human breast adenocarcinoma cell line, we performed a microarray analysis from RNAs isolated from MCF-7 cells expressing either an empty vector (CTRL) or human MMP-14 cDNA ...
ORGANISM(S): Homo sapiens 
2014-12-15 | E-GEOD-49595 | biostudies-arrayexpress
UnknownCell-Laden 3D Hydrogels of Type I Collagen Incorporating Bacterial Nanocellulose Fibers.
Not available
S-EPMC10521014 | biostudies-literature
TranscriptomicsComparison of the effects of five dietary fibers on mucosal transcriptional profiles, and luminal microbiota composition and SCFA concentrations in murine colon
Consumption of diets rich in fibers has been associated with several beneficial effects on gastrointestinal health. However, detailed studies on the molecular effects of fibers in colon are limited. In this study we investigated and compared the influence of five different fibers on the mucosal tran...
ORGANISM(S): Mus musculus 
2015-05-26 | E-GEOD-59494 | biostudies-arrayexpress
UnknownMechanistic Insight into the Fragmentation of Type I Collagen Fibers into Peptides and Amino Acids by a Vibrio Collagenase.
Not available
S-EPMC9004396 | biostudies-literature
UnknownStructural Breakdown of Collagen Type I Elastin Blend Polymerization.
Not available
S-EPMC9611167 | biostudies-literature
ProteomicsSecretome analysis of mouse fibroblast
Fibrillin-1, an extracellular matrix (ECM) protein encoded by FBN1 gene, serves as the microfibril scaffold crucial for elastic fiber formation and homeostasis in pliable tissue such as the skin. Besides causing Marfan syndrome, some mutations in FBN1 result in scleroderma, marked by hardened and th...
ORGANISM(S): Mus Musculus (mouse) 
2025-04-11 | PXD052580 | JPOST Repository
UnknownNanomechanics of Type I Collagen.
Not available
S-EPMC4945622 | biostudies-literature
UnknownMicroextrusion printing cell-laden networks of type I collagen with patterned fiber alignment and geometry.
Not available
S-EPMC6639139 | biostudies-literature
UnknownCarcinomas contain a matrix metalloproteinase-resistant isoform of type I collagen exerting selective support to invasion.
Not available
S-EPMC2880213 | biostudies-literature
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