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TranscriptomicsMacrophages recognize the Helicobacter pylori type IV secretion system in the absence of TLR signaling
Helicobacter pylori conquered the world by colonizing the human stomach. There are two major groups of strains, one with and one without a cag pathogenicity island (cagPAI), which result in different clinical outcomes with increased severity in cagPAI+ H. pylori infections such as higher inflammatio...
ORGANISM(S): Mus musculus 
2015-09-01 | E-GEOD-56791 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse splenocytes response to infection with wild type or virB mutant Brucella strains
The virB operon, encoding a Type IV secretion system (T4SS), is essential for intracellular survival and persistent infection of Brucella spp. To better understand the role of the T4SS in evading host defense mechanisms and establishing chronic infection, we compared transcriptional profiles of the ...
ORGANISM(S): Mus musculus 
2008-11-06 | E-GEOD-6810 | biostudies-arrayexpress
ProteomicsAnalysis of secretion of transmembrane effectors by the type IV b secretion system of Legionella pneumophila
In order to promote intracellular survival and infection, Legionella spp. translocate hundreds of effector proteins into eukaryotic host cells using a type IV b protein secretion system (T4bSS). T4bSS are well known to translocate soluble as well as transmembrane domain-containing effector proteins ...
ORGANISM(S): Legionella pneumophila 
2024-10-15 | PXD050153 | Pride
Type iv secretion system Effector Legionella Bacterial inner membrane 
ProteomicsLysyl hydroxylase 3 mediated post-translational modifications are required for proper biosynthesis of collagen a1a1a2(IV)
We performed proteomic identification of type IV collagen gel bands from wild-type and lysyl hydroxylase 3 knockout cells by LC-MS after trypsin digestion.
ORGANISM(S): Mus Musculus (mouse) 
2022-11-21 | PXD035051 | JPOST Repository
GenomicsMolecular mechanisms of two-component system RhpRS regulating type III secretion system in Pseudomonas syringae
Pseudomonas syringae uses two-component system RhpRS to regulate the expression of type III secretion system (T3SS) genes and bacterial virulence. However, the molecular mechanism and the regulons of RhpRS have yet to be fully elucidated. Here we show that RhpS functions as an autokinase, an RhpR ki...
ORGANISM(S): Pseudomonas syringae pv. phaseolicola 
2014-10-01 | E-GEOD-58533 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human A549 pneumocyte cells infected with wild type and type III secretion system mutants of Pseudomonas aeruginosa
The bacterial type III secretion system (TTSS) is dedicated to directly effect host cell pathways by pathogens. In order to identify the key host responses of the various parts of the TTSS, we utilized expression profiling of a lung pneumocytes cell line, A549, exposed to various isogenic mutant str...
ORGANISM(S): Homo sapiens 
2007-08-03 | E-GEOD-1469 | biostudies-arrayexpress
TranscriptomicsMicroarray of Genes affected by BlxR deletion
A mini-microarray containing spotted oligos corresponding to 289 B. melitensis genes was used to identify candidate genes whose transcription is influenced by BlxR. This microarray contains genes encoding the type IV secretion system, flagella, transcriptional regulators, transporters, and proteins...
ORGANISM(S): Brucella melitensis 
2008-04-30 | E-GEOD-10735 | biostudies-arrayexpress
GenomicsCoxiella burnetii type IV secretion-mediated activation of host cell Nrf2 signaling
Coxiella burnetii type IV secretion-mediated activation of host cell Nrf2 signaling
PRJNA1023926 | ENA
ProteomicsNaringenin targets PI3K p85alpha to suppress PI3K/AKT signaling pathway and ameliorate disordered MMP-9 secretion in cigarette smoke extract-induced alveolar macrophages in vitro
Naringenin has demonstrated potential therapeutic effects against cigarette smoke-induced lung injury; however, its underlying mechanisms of regulating matrix metalloproteinase-9 (MMP-9) in alveolar macrophages remain unclear. Methods: The regulatory mechanisms of naringenin in cigarette smoke extra...
ORGANISM(S): Mus Musculus 
PXD063137 |
TranscriptomicsSecretion stress caused by overexpression of heterologous α-amylase in Bacillus subtilis
Transcriptome analysis was used to investigate the global stress response of the Gram-positive bacterium Bacillus subtilis caused by overproduction of the well-secreted AmyQ α-amylase from Bacillus amyloliquefaciens. Analyses of the control and overproducing strains were carried out at the end of ex...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2007-10-01 | E-GEOD-8014 | biostudies-arrayexpress
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