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MetabolomicsCharacterization of active peptides derived from three leeches and comparison of their anti-thrombotic mechanisms using the tail vein thrombosis model in mice and metabonomics

BACKGROUND AND AIMS: The increasing incidence of cardiovascular diseases has created an urgent need for safe and effective anti-thrombotic agents. Leech, as a traditional Chinese medicine, has the effect of promoting blood circulation and removing blood stasis, but its real mater...

2024-01-18 | MTBLS9306 | MetaboLights
TranscriptomicsmRNA Poly(A)-tail Changes Specified by Deadenylation Broadly Reshape Translation in Drosophila Oocytes and Early Embryos
Because maturing oocytes and early embryos lack transcription, posttranscriptional regulatory processes must control their development. To better understand this control, we profiled translational efficiencies and poly(A)-tail lengths throughout Drosophila oocyte maturation and early embryonic deve...
ORGANISM(S): Drosophila melanogaster 
2016-08-08 | E-GEOD-83616 | biostudies-arrayexpress
TranscriptomicsBehavioural and brain gene expression profiling in pigs during tail biting outbreaks - evidence of a tail biting resistant phenotype
Brain gene expression in pigs housed in a pen during a tail biting outbreak compared with pigs housed in control pens.
ORGANISM(S): Sus scrofa 
2012-09-30 | E-MEXP-3643 | biostudies-arrayexpress
MetabolomicsMetabolic Biomarkers of Ageing in C57BL/6J Wild-Type and Flavin-Containing Monooxygenase 5 (FMO5)-Knockout Mice
It was recently demonstrated in mice that knockout of the flavin-containing monooxygenase 5 gene, Fmo5, slows metabolic ageing via pleiotropic effects. We have now used an NMR-based metabonomics approach to study the effects of ageing directly on the metabolic profiles of urine and plasma from male,...
2018-06-20 | MTBLS667 | MetaboLights
MetabolomicsN-glycosylation Profiling of Colorectal Cancer Cell Lines Reveals Association of Fucosylation with Differentiation and Caudal Type Homebox 1 (CDX1)/Villin mRNA Expression
Various cancers such as colorectal cancer (CRC) are associated with alterations in protein glycosylation. CRC cell lines are frequently used to study these (glyco)biological changes and their mechanisms. However, differences between CRC cell lines with regard to their glycosylation have hitherto bee...
2017-02-03 | MTBLS227 | MetaboLights
TranscriptomicsTranscription profiling of mouse B cells expressing anti-HEL IgM BCR and IgMG BCR to investigate the effect of IgG cytoplasmic tail on BCR-respose genes
IgG cytoplasmic tail interferes with the induction of antigen-response genes Experiment Overall Design: Comparing antigen-induced genes between B cells expressing anti-HEL IgM BCR and IgMG BCR (chimeric receptor where the extracellular spacer, transmembrane, and cytoplasmic domain of IgM are replace...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7218 | biostudies-arrayexpress
TranscriptomicsBrain gene expression differences are associated with abnormal tail biting behavior in pigs
Gene expression in the hypothalamus and pre frontal cortex in pigs performing and receiving tail biting behaviour was compared with expression in pigs not performing or receiving tail biting
ORGANISM(S): Sus scrofa 
2013-11-12 | E-MEXP-3630 | biostudies-arrayexpress
TranscriptomicsPoly(A) tail length profiling of mRNAs from fission yeast
To obtain global data on polyadenylation of mRNAs, we fractionated the mRNAs according to their poly(A) tail length using a poly-U sepharose column followed by differential elution at five temperatures. Five mRNA fractions with distinct ranges of poly(A) tail length were then hybridized to microarr...
ORGANISM(S): Schizosaccharomyces pombe 
2007-05-16 | E-TABM-217 | biostudies-arrayexpress
TranscriptomicsExpression data from tail skin in young (5 months) and old (30 months) CB6F1 mice
Background: Skin aging is associated with intrinsic processes that compromise structure of the extracellular matrix while promoting loss of functional and regenerative capacity. These processes are accompanied by a large-scale shift in gene expression, but underlying mechanisms are not understood an...
ORGANISM(S): Mus musculus 
2012-03-15 | E-GEOD-35322 | biostudies-arrayexpress
TranscriptomicsEffect of loss of function of Gal11/Med15 and Med3 from the Mediator tail module in budding yeast
Gene expression was compared for wild type yeast (BY4741) and yeast lacking Gal11/Med15 and Med3, or from a gal11-myc med3∆ strain. The gal11-myc allele shows a partial loss of function when combined with med3∆. Expression was analyzed for yeast grown in YPD as well as in CSM. We also examined...
ORGANISM(S): Saccharomyces cerevisiae 
2011-08-31 | E-GEOD-31774 | biostudies-arrayexpress
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