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TranscriptomicsSHAPE-Seq of human U2 snRNA and U4 pre-snRNA
Spliceosomal snRNA are key components of small nuclear ribonucleoprotein particles (snRNPs), the building blocks of the spliceosome. The biogenesis of snRNPs is a complex process involving multiple cellular and subcellular compartments, the details of which are yet to be described. In short, the snR...
ORGANISM(S): Homo sapiens 
2023-09-08 | E-MTAB-13248 | biostudies-arrayexpress
ProteomicsCAPTURE of the human U2 snRNA genes
In order to identify factors involved in transcription of human snRNA genes and 3’ end processing of the transcripts, we have carried out CRISPR affinity purification in situ of regulatory elements (CAPTURE), which is deadCas9-mediated pull-down, of the tandemly-repeated U2 snRNA genes in human cell...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD033580 | Pride
Transcription Snrna Interactome 
ProteomicsIdentification of U1 snRNA associated proteins
In this project, we isolate U1 snRNA associated proteins in Arabidopsis thaliana. We used an antisense oligonucleotide specific for the U1 snRNA and analyzed associated proteins by mass spectrometry. As a control, the same experiments were performed with U2 snRNA- and lacZ-specifc antisense oligonuc...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2023-12-04 | PXD045484 | Pride
U1 snrna Arabidopsis U2 snrna Comprehensive isolation by rna binding proteins (chirp) 
GenomicsSHAPE-Seq of human U2 snRNA and U4 pre-snRNA
SHAPE-Seq of human U2 snRNA and U4 pre-snRNA
PRJEB65050 | ENA
TranscriptomicsCirculating U2 small nuclear RNA fragments as a novel diagnostic biomarker for pancreatic and colorectal adenocarcinoma
Global microRNA expression profiling of serum were collected using Agilent miRNA microarrays (G4471A Human, Amadid 29297, Sanger 14) carrying 887 individual human miRNA probes. Two different sources of RNA were analyzed: serum from NMRI-nu/nu mice carrying a xenograft tumor derived from human prima...
ORGANISM(S): Homo sapiens 
2013-07-01 | E-GEOD-34052 | biostudies-arrayexpress
GenomicsMETTL4 catalyzes m6Am methylation in U2 snRNA to regulate pre-mRNA splicing
METTL4 catalyzes m6Am methylation in U2 snRNA to regulate pre-mRNA splicing
PRJNA604769 | ENA
TranscriptomicsIdentification of the altered transcripts in the NMF291–/– cerebellum by exon array.
The U2 snRNA is a basal component of the major spliceosome, which is responsible for >90% human pre-mRNA splicing. A 5-nucleotide deletion in one of the mouse U2 snRNA genes (Rnu2-8) causes cerebellar granule cell degeneration in the NMF291 mouse mutant strain. To identify the altered transcripts in...
ORGANISM(S): Mus musculus 
2011-10-19 | E-GEOD-33069 | biostudies-arrayexpress
GenomicsCAPTURE of the human U2 snRNA genes expands the repertoire of associated factors.
CAPTURE of the human U2 snRNA genes expands the repertoire of associated factors.
PRJNA810044 | ENA
UnknownMETTL4 catalyzes m6Am methylation in U2 snRNA to regulate pre-mRNA splicing.
Not available
S-EPMC7498333 | biostudies-literature
UnknownStructure of the yeast U2/U6 snRNA complex.
Not available
S-EPMC3312555 | biostudies-literature
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