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Mpn1 proteins are evolutionarily conserved exonucleases that modify spliceosomal U6 small nuclear RNAs (snRNAs) post-transcriptionally. Mutations in the human MPN1 gene are associated to the genodermatosis Clericuzio-type poikiloderma with neutropenia (PN). Mpn1 deficiency leads to aberrant U6 3M-bM...
ORGANISM(S): Schizosaccharomyces pombe 
THUMPD2 installs N2-methylguanosine (m2G) at position 72 of the U6 snRNA, and this modification, which lies at the catalytic core of the spliceosome, is required for efficient splicing of weak splice sites. However, when during the U6 lifecycle this modification is installed and what features of the...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD053510 | Pride
RNA ligation precedes U6 snRNA/LINE-1 retrotransposition
RNA ligation precedes U6 snRNA/LINE-1 retrotransposition
MMARY THUMPD2 installs N2-methylguanosine (m2G) at position 72 of the U6 snRNA, and this modification, which lies at the catalytic core of the spliceosome, is required for efficient splicing of weak splice sites. However, when during the U6 lifecycle this modification is installed and what features ...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD053619 | Pride
RiboMeth-Seq analysis of purified U6 and U2 snRNAs
Mpn1 proteins are evolutionarily conserved exonucleases that modify spliceosomal U6 small nuclear RNAs (snRNAs) post-transcriptionally. Mutations in the human MPN1 gene are associated to the genodermatosis Clericuzio-type poikiloderma with neutropenia (PN). Mpn1 deficiency leads to aberrant U6 3’ en...
ORGANISM(S): Schizosaccharomyces pombe 
2014-08-08 | GSE60195 | GEO
U6 snRNP inhibits the premature cleavage and polyadenylation of pre-mRNAs (RNA-Seq)
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