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ProteomicsComposition and processing activity of a semi-recombinant holo U7 snRNP
In animal cells, replication-dependent histone pre-mRNAs are cleaved at the 3’ end by U7 snRNP consisting of two core components: a ~60-nucleotide U7 snRNA and a ring of seven proteins, with Lsm10 and Lsm11 replacing the spliceosomal SmD1 and SmD2. Lsm11 interacts with FLASH and together they recrui...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-25 | PXD014164 | Pride
Sm proteins U7 snrnp Cpsf73 Lsm11 Flash Histone pre-mrna 3’ end processing 
ProteomicsProtein composition of catalytically active U7-dependent processing complexes assembled on histone pre-mRNA containing biotin and a photo-cleavable linker
To identify components of the U7 snRNP, we used cleavage-resistant histone pre-mRNA containing biotin and a photo-sensitive linker and purify processing complexes from Drosophila and mouse nuclear extracts.
ORGANISM(S): Mus musculus (Mouse) Drosophila melanogaster (Fruit fly) 
2018-03-08 | PXD008917 | Pride
Flash  lsm11 Histone pre-mrna Photo-cleavable linker 3’ end processing U7 snrnp  slbp 
GenomicsSUMO2 Regulates Histone Pre-mRNA Processing by Stabilizing Histone Locus Body Interactions and Promoting U7 snRNP Assembly
SUMO2 Regulates Histone Pre-mRNA Processing by Stabilizing Histone Locus Body Interactions and Promoting U7 snRNP Assembly
PRJNA1241289 | ENA
UnknownSMN controls neuromuscular junction integrity through U7 snRNP.
Not available
S-EPMC9533342 | biostudies-literature
TranscriptomicsSUMO2 Regulates Histone Pre-mRNA Processing by Stabilizing Histone Locus Body Interactions and Promoting U7 snRNP Assembly
Histone mRNAs are the only non-polyadenylated mRNAs in eukaryotic cells and require specialized processing in nuclear organelles known as histone locus bodies (HLBs), where essential processing factors are concentrated, including the U7 snRNP complex. Recent studies have revealed that misregulation ...
ORGANISM(S): Homo sapiens 
2025-03-29 | GSE292809 | GEO
UnknownComposition and processing activity of a semi-recombinant holo U7 snRNP.
Not available
S-EPMC7026596 | biostudies-literature
UnknownU2 snRNP binds intronless histone pre-mRNAs to facilitate U7-snRNP-dependent 3' end formation.
Not available
S-EPMC2149891 | biostudies-literature
UnknownSUMO2 promotes histone pre-mRNA processing by stabilizing histone locus body interactions and facilitating U7 snRNP assembly.
Not available
S-EPMC12305476 | biostudies-literature
UnknownIn vitro methylation of the U7 snRNP subunits Lsm11 and SmE by the PRMT5/MEP50/pICln methylosome.
Not available
S-EPMC10578488 | biostudies-literature
UnknownAn N-terminal helix of Lsm11 stabilizes CPSF73 in U7 snRNP for histone pre-mRNA 3'-end processing.
Not available
S-EPMC12774660 | biostudies-literature
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