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ProteomicsThiocarboxylation of Urm1 is regulated by tightly-controlled biochemical checkpoints
Ubiquitin related modifier 1 (Urm1) is a highly conserved member of the Ubiquitin-like (UBL) family of proteins. Urm1 is a key component of the eukaryotic thiolation cascade, which is responsible for introducing sulfur at U34 in several eukaryotic tRNAs. Like other UBLs, Urm1 is also able to conjuga...
ORGANISM(S): Chaetomium Thermophilum (ncbitaxon:209285) Saccharomyces Cerevisiae (ncbitaxon:4932) 
2024-02-22 | MSV000094152 | MassIVE
ProteomicsMolecular characterization of the eukaryotic Uba4/Urm1 system
Ubiquitin-like protein activator 4 (Uba4) is required for the thiolation of uridine bases in eukaryotic transfer RNA. Uba4 catalyzes the sequential adenylation and thiocarboxylation of the C-terminus of Ubiquitin related modifier 1 (Urm1), acting as a hybrid between an E1-like activating enzyme and ...
ORGANISM(S): Chaetomium thermophilum 
2020-07-14 | PXD015802 | Pride
Uba4 Urmylation Urm1 
ProteomicsMolecular basis for thiocarboxylation and release of Urm1 by its E1-activating enzyme Uba4
Ubiquitin related modifier 1 (Urm1) is a highly conserved member of the Ubiquitin-like (UBL) family of proteins. Urm1 is a key component of the eukaryotic thiolation cascade, which is responsible for introducing sulfur at U34 in several eukaryotic tRNAs. Like other UBLs, Urm1 is also able to conjuga...
ORGANISM(S): Chaetomium Thermophilum (ncbitaxon:209285) Saccharomyces Cerevisiae (ncbitaxon:4932) 
2024-08-19 | MSV000095642 | MassIVE
UnknownMolecular basis for thiocarboxylation and release of Urm1 by its E1-activating enzyme Uba4.
Not available
S-EPMC11662940 | biostudies-literature
UnknownMolecular basis for the bifunctional Uba4-Urm1 sulfur-relay system in tRNA thiolation and ubiquitin-like conjugation.
Not available
S-EPMC7527816 | biostudies-literature
UnknownThe Uba4 domain interplay is mediated via a thioester that is critical for tRNA thiolation through Urm1 thiocarboxylation.
Not available
S-EPMC6007339 | biostudies-literature
UnknownSulfur transfer and activation by ubiquitin-like modifier system Uba4•Urm1 link protein urmylation and tRNA thiolation in yeast.
Not available
S-EPMC5349211 | biostudies-literature
TranscriptomicsCodon-mediated translational control of M. oryzae effectors
Magnaporthe oryzae, the fungus causing rice blast disease, deploys effectors to manipulate host immunity. Apoplastic effectors are secreted conventionally, whereas cytoplasmic effectors are deployed into the biotrophic interfacial complex (BIC) via the unconventional protein secretion (UPS) pathway....
ORGANISM(S): Oryza sativa 
2025-11-17 | GSE297821 | GEO
ProteomicsE2/E3-independent ubiquitin-like protein conjugation by Urm1 is directly coupled to cysteine persulfidation
Posttranslational modifications by ubiquitin-like proteins (UBL) are essential for nearly all cellular processes. Ubiquitin related modifier 1 (Urm1) is a non-canonical UBL which plays a key role in tRNA anticodon thiolation as a sulfur carrier protein (SCP). While Urm1 has also been observed to con...
ORGANISM(S): Chaetomium Thermophilum (ncbitaxon:209285) Saccharomyces Cerevisiae (ncbitaxon:4932) Homo Sapiens (ncbitaxon:9606) 
2021-11-16 | MSV000088390 | MassIVE
UnknownE2/E3-independent ubiquitin-like protein conjugation by Urm1 is directly coupled to cysteine persulfidation.
Not available
S-EPMC9574740 | biostudies-literature
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