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ProteomicsMolecular characterization of the eukaryotic Uba4/Urm1 system
Ubiquitin-like protein activator 4 (Uba4) is required for the thiolation of uridine bases in eukaryotic transfer RNA. Uba4 catalyzes the sequential adenylation and thiocarboxylation of the C-terminus of Ubiquitin related modifier 1 (Urm1), acting as a hybrid between an E1-like activating enzyme and ...
ORGANISM(S): Chaetomium thermophilum 
2020-07-14 | PXD015802 | Pride
Uba4 Urmylation Urm1 
ProteomicsThiocarboxylation of Urm1 is regulated by tightly-controlled biochemical checkpoints
Ubiquitin related modifier 1 (Urm1) is a highly conserved member of the Ubiquitin-like (UBL) family of proteins. Urm1 is a key component of the eukaryotic thiolation cascade, which is responsible for introducing sulfur at U34 in several eukaryotic tRNAs. Like other UBLs, Urm1 is also able to conjuga...
ORGANISM(S): Chaetomium Thermophilum (ncbitaxon:209285) Saccharomyces Cerevisiae (ncbitaxon:4932) 
2024-02-22 | MSV000094152 | MassIVE
ProteomicsE2/E3-independent ubiquitin-like protein conjugation by Urm1 is directly coupled to cysteine persulfidation
Posttranslational modifications by ubiquitin-like proteins (UBL) are essential for nearly all cellular processes. Ubiquitin related modifier 1 (Urm1) is a non-canonical UBL which plays a key role in tRNA anticodon thiolation as a sulfur carrier protein (SCP). While Urm1 has also been observed to con...
ORGANISM(S): Chaetomium Thermophilum (ncbitaxon:209285) Saccharomyces Cerevisiae (ncbitaxon:4932) Homo Sapiens (ncbitaxon:9606) 
2021-11-16 | MSV000088390 | MassIVE
GenomicsNAE1/UBA3-UBE2M are E1 and E2 Enzymes for the Urm1 Modification in Human Cells
NAE1/UBA3-UBE2M are E1 and E2 Enzymes for the Urm1 Modification in Human Cells
PRJNA1307993 | ENA
ProteomicsStress Dependent Condensate Formation Regulated by the Ubiquitin Related Modifier Urm1
The ability of proteins and RNA to coalesce into phase-separated assemblies is an emergent principle in organizing membraneless cellular compartments such as stress granules (SGs) and the nucleolus. While the individual constituents of these compartments have become increasingly well documented, the...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-06-28 | PXD044486 | Pride
Yeast urm1 
TranscriptomicsNAE1/UBA3-UBE2M are E1 and E2 Enzymes for the Urm1 Modification in Human Cells
Ubiquitin-related modifier 1 (Urm1) is an evolutionarily conserved ubiquitin-like protein. In eukaryotes, it serves dual roles as a sulfur donor for tRNA modification and a posttranslational protein modifier. Urm1 is proposed to be a primitive protein modifier and a potential precursor to the more c...
ORGANISM(S): Homo sapiens 
2026-03-23 | GSE305835 | GEO
UnknownUrm1: A Non-Canonical UBL.
Not available
S-EPMC7911844 | biostudies-literature
ProteomicsNAE1/UBA3-UBE2M are E1 and E2 Enzymes for the URM1 Modification in Human Cells
The Urm1 protein, a member of the ubiquitin (Ub)-related modifier family, is highly conserved across evolution and plays a crucial role as a sulfur donor in tRNA thiolation. Despite its importance, Urm1 remains relatively understudied in mammalian eukaryotes, leading to numerous unknown functions...
ORGANISM(S): Homo sapiens (Human) 
2026-03-23 | PXD067405 | Pride
E1/e2 enzymes lc-ms/ms 
UnknownUrm1, not quite a ubiquitin-like modifier?
Not available
S-EPMC8561144 | biostudies-literature
UnknownMolecular basis for thiocarboxylation and release of Urm1 by its E1-activating enzyme Uba4.
Not available
S-EPMC11662940 | biostudies-literature
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