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ProteomicsFine-tuning of mTOR signaling by the UBE4B-KLHL22 E3 ubiquitin ligase cascade in brain development
Abstract Spatiotemporal regulation of the mechanistic target of rapamycin (mTOR) pathway is pivotal for establishment of brain architecture. Dysregulation of mTOR signaling is associated with a variety of neurodevelopmental disorders (NDDs). Here, we discover that the UBE4B-KLHL22 E3 ubiquitin ligas...
ORGANISM(S): Mus musculus (Mouse) 
2022-12-12 | PXD035852 | Pride
Mouse brain Ms Ube4b 
TranscriptomicsExpression analysis of single and double knockdown of UBE4B and LSD1 in HEK293T cells.
Ubiquitin Ligase (UBE4B) and Lysine-Specific Demethylase (LSD1) are post-translational modifying enzymes affecting lysine ubiquitination and methylation of several important regulatory proteins, and are synergisticaly important for protein quality control. To inwestigate their role in cell signaling...
ORGANISM(S): Homo sapiens 
2017-02-09 | GSE58026 | GEO
UnknownThe SWIB/MDM2 motif of UBE4B activates the p53 pathway.
Not available
S-EPMC9971181 | biostudies-literature
UnknownUBE4B targets phosphorylated p53 at serines 15 and 392 for degradation.
Not available
S-EPMC4823074 | biostudies-literature
UnknownUBE4B Mediates Mitophagy via NIPSNAP1 Ubiquitination and NDP52 Recruitment.
Not available
S-EPMC12842286 | biostudies-literature
UnknownUBE4B promotes gastric cancer proliferation and metastasis by mediating FAT4 ubiquitination and degradation.
Not available
S-EPMC12287395 | biostudies-literature
UnknownFine-tuning of mTOR signaling by the UBE4B-KLHL22 E3 ubiquitin ligase cascade in brain development.
Not available
S-EPMC9845739 | biostudies-literature
UnknownNeuroblastoma patient outcomes, tumor differentiation, and ERK activation are correlated with expression levels of the ubiquitin ligase UBE4B.
Not available
S-EPMC4773702 | biostudies-literature
UnknownDeciphering UBE4B phosphorylation dynamics: a key mechanism in p53 accumulation and cancer cell response to DNA damage.
Not available
S-EPMC11965332 | biostudies-literature
UnknownUBE4B interacts with the ITCH E3 ubiquitin ligase to induce Ku70 and c-FLIPL polyubiquitination and enhanced neuroblastoma apoptosis.
Not available
S-EPMC10643674 | biostudies-literature
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