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ProteomicsFBXL13 regulates centrosome homeostasis and migration through ubiquitin- mediated proteolysis
Aberrant centrosome organization with ensuing alterations of microtubule nucleation enables tumor cells to proliferate and invade despite increased genomic instability. CEP192 is a key factors in the initiation process of centrosome duplication and in the control of centrosome microtubule nucleation...
ORGANISM(S): Homo sapiens (Human) 
2018-01-16 | PXD008310 | Pride
Ubiquitin fbxl13 
ProteomicsFbxl13 regulates centrosome homeostasis and migration through ubiquitin mediated proteolysis
F-box proteins are the variable substrate adaptor subunits of the SCF (Skp1, Cul1, F-box) ubiquitin ligases. The family comprise about 69 members with important roles in cancer pathogenesis and cell proliferation. Among the F-box proteins, Fbxl13 is frequently amplified in several cancer patient coh...
ORGANISM(S): Homo sapiens (Human) 
2022-03-02 | PXD006756 | Pride
Ubiquitin ligase Hek293t Fbxl13 Orbitrap elite F-box protein 
UnknownFBXL13 directs the proteolysis of CEP192 to regulate centrosome homeostasis and cell migration.
Not available
S-EPMC5836097 | biostudies-literature
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