Fbxl13 - OmicsDI

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FBXL13 regulates centrosome homeostasis and migration through ubiquitin- mediated proteolysis

Aberrant centrosome organization with ensuing alterations of microtubule nucleation enables tumor cells to proliferate and invade despite increased genomic instability. CEP192 is a key factors in the initiation process of centrosome duplication and in the control of centrosome microtubule nucleation...

ORGANISM(S): Homo sapiens (Human)

2018-01-16 | PXD008310 | Pride

Ubiquitin fbxl13

Fbxl13 regulates centrosome homeostasis and migration through ubiquitin mediated proteolysis

F-box proteins are the variable substrate adaptor subunits of the SCF (Skp1, Cul1, F-box) ubiquitin ligases. The family comprise about 69 members with important roles in cancer pathogenesis and cell proliferation. Among the F-box proteins, Fbxl13 is frequently amplified in several cancer patient coh...

ORGANISM(S): Homo sapiens (Human)

2022-03-02 | PXD006756 | Pride

Ubiquitin ligase Hek293t Fbxl13 Orbitrap elite F-box protein

FBXL13 directs the proteolysis of CEP192 to regulate centrosome homeostasis and cell migration.

Not available

S-EPMC5836097 | biostudies-literature

Nexin-Dynein regulatory complex component DRC7 but not FBXL13 is required for sperm flagellum formation and male fertility in mice.

Not available

S-EPMC6994161 | biostudies-literature

A Genome-Wide Association Study and Complex Network Identify Four Core Hub Genes in Bipolar Disorder.

Not available

S-EPMC5751362 | biostudies-literature