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ProteomicsQuantitative Measurement of the Requirement of Diverse Protein Degradation Pathways in MHC Class I Peptide Presentation
The adaptive immune system distinguishes self from non-self by surveying peptides generated from degradation of intracellular proteins that are loaded onto MHC Class I molecules for display on the cell surface. While early studies reported that the bulk of cell surface MHC Class I complexes require ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-02-15 | MSV000091285 | MassIVE
TranscriptomicsPost-transcriptional fine-tuning of COP9 signalosome subunit biosynthesis is regulated by the c-Myc/Lin28B/let-7 pathway
The COP9 signalosome (CSN) is a conserved protein complex occurring in all eukaryotes. The mammalian CSN consists of eight subunits (CSN1 – CSN8) and possesses an intrinsic metalloprotease JAMM motif localised to CSN5. In addition, it is associated with kinases such as protein kinase CK2 and D and t...
ORGANISM(S): Homo sapiens 
2011-10-26 | E-GEOD-19085 | biostudies-arrayexpress
TranscriptomicsRNAi knock down of VCP in human HeLa cells
Study of the effects of the VCP knockdown. VCP (p97, yeast cdc48) is a hexameric AAA ATPase involved in various cellular functions including degradation of proteins by the ubiquitin-proteasome system. We examine the consequences of the reduction of VCP levels after RNAi of VCP in HeLa cells. We find...
ORGANISM(S): Homo sapiens 
2006-08-23 | E-MEXP-817 | biostudies-arrayexpress
UnknownActivation of the ubiquitin-proteasome system contributes to oculopharyngeal muscular dystrophy through muscle atrophy.
Not available
S-EPMC8791501 | biostudies-literature
TranscriptomicsExpression data from embryonic stem cells following siRNA transfection of UPS members [self_renewal]
While transcriptional regulation of stem cell self-renewal and differentiation has been extensively studied, only a small number of studies have addressed the roles for post-translational modifications in these processes. A key mechanism of post-translational modification is ubiquitination by the u...
ORGANISM(S): Mus musculus 
2012-07-31 | E-GEOD-39771 | biostudies-arrayexpress
TranscriptomicsExpression data from embryonic stem cells following siRNA transfection of UPS members [Differentiation_ES]
While transcriptional regulation of stem cell self-renewal and differentiation has been extensively studied, only a small number of studies have addressed the roles for post-translational modifications in these processes. A key mechanism of post-translational modification is ubiquitination by the u...
ORGANISM(S): Mus musculus 
2012-07-31 | E-GEOD-39770 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human cell cancer line treated with bortezomib or Eeyarestatin I (EerI) reveals ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3 only protein NOXA in cancer cells
The ubiquitin-proteasome system (UPS) has recently emerged as a major target for drug development in cancer therapy. The proteasome inhibitor bortezomib has clinical activity in multiple myeloma and mantle cell lymphoma. Here we report that Eeyarestatin I (EerI), a chemical inhibitor that blocks ER-...
ORGANISM(S): Homo sapiens 
2009-02-28 | E-GEOD-14003 | biostudies-arrayexpress
OtherA systems-wide screen identifies substrates of the SCF-beta-TrCP ubiquitin ligase.
Data from ProteomeXchange, PXD ID: PXD001224. File: OR3_100623_BTrCP_EV_IP_Band01.mzml. Published as part of Sci Signal. 2014 Dec 16;7(356):rs8 . From the Abstract: {{i}} ... We developed a combined bioinformatics and affinity purification-mass spectrometry (AP-MS) workflow for the system-wide iden...
ORGANISM(S): Homo_sapiens_viruses, Human_female 
GPM32320006530 | GPMDB
Resource Reanalysis 
UnknownRegulation of STIM1 and SOCE by the ubiquitin-proteasome system (UPS).
Not available
S-EPMC2956693 | biostudies-literature
ProteomicsProteomics identifies ubiquitin-proteasome targets and new roles for chromatin-remodelling in the Arabidopsis response to phosphate starvation
In order to identify new regulators of the phosphate (Pi) starvation signaling pathway in plants, we analyzed variation in the abundance of nuclear-enriched nuclear proteins isolated from Arabidopsis roots that depends on Pi supply. We used 2-D Fluorescence Difference Gel Electrophoresis and MALDI-T...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2020-01-22 | PXD000305 | Pride
Arabidopsis Nuclear proteome Ubiquitin-proteasome system Nap1 2 Dige Phosphate signaling Phosphate starvation Histone chaperone 
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