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UnknownRemoval of H2Aub1 by ubiquitin-specific proteases 12 and 13 is required for stable Polycomb-mediated gene repression in Arabidopsis.
Not available
S-EPMC7296913 | biostudies-literature
ProteomicsUSP36-mediated deubiquitination of DOCK4 contributes to the diabetic renal tubular epithelial cell injury via Wnt/β-catenin signaling pathway
Diabetic kidney disease (DKD) has become the leading cause of end-stage renal diseases, but the efficacy of current treatment remains unsatisfactory. The pathogenesis of DKD needs a more in-depth research. Ubiquitin specific proteases 36 (USP36), a member of deubiquitinating enzymes family, has arou...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD023347 | Pride
Dedicator of cytokinesis 4 Deubiquitination Epithelial-to-mesenchymal transition Diabetic kidney disease Ubiquitin specific proteases 36 Wnt/β-catenin 
ProteomicsComparative analyses of Netherton syndrome patients and Spink5 conditional knock-out mice define disease-relevant pathways
Netherton syndrome (NS) is a rare skin disease caused by loss-of-function mutations in the serine peptidase inhibitor Kazal type 5 (SPINK5) gene. Disease severity and the lack of efficacious treatments call for a better understanding of NS mechanisms. Here we describe a viable, Spink5 conditional kn...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-02-02 | MSV000091184 | MassIVE
UnknownCoronaviral PLpro proteases and the immunomodulatory roles of conjugated versus free Interferon Stimulated Gene product-15 (ISG15).
Not available
S-EPMC9233553 | biostudies-literature
ProteomicsComprehensive landscape of active deubiquitinating enzymes profiled by advanced chemoproteomics
Enzymes that bind and process ubiquitin, a small 76 amino acid protein, have been recognized as pharmacological targets in oncology, immunological disorders and neurodegeneration. Mass spectrometry technology has now reached the capacity to cover the proteome with enough depth to interrogate entire ...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD014391 | Pride
Proteomics Mass spectrometry Deubiquitylating enzymes Chemical biology Isoforms Ubiquitin specific proteases 
UnknownIdentification of New Degrons in Streptococcus mutans Reveals a Novel Strategy for Engineering Targeted, Controllable Proteolysis.
Not available
S-EPMC5742171 | biostudies-literature
UnknownUSP36-Mediated Deubiquitination of DOCK4 Contributes to the Diabetic Renal Tubular Epithelial Cell Injury via Wnt/β-Catenin Signaling Pathway.
Not available
S-EPMC8102983 | biostudies-literature
ProteomicsExome Sequencing Links the SUMO Protease SENP7 with Fatal Arthrogryposis Multiplex Congenita, Early Respiratory Failure, and Neutropenia
SUMOylation involves the attachment of Small Ubiquitin-like Modifier (SUMO) proteins to specific lysine residues on thousands of substrates with various effects on protein function. Sentrin-specific proteases (SENPs) are proteins involved in the maturation and de-conjugation of SUMO. Specifically, S...
ORGANISM(S): Homo sapiens (Human) 
2023-07-26 | PXD040206 | Pride
Human Fibroblast Patient Mutation 
UnknownLoss of the deubiquitinase USP36 destabilizes the RNA helicase DHX33 and causes preimplantation lethality in mice.
Not available
S-EPMC5808777 | biostudies-literature
UnknownDistribution and paralogue specificity of mammalian deSUMOylating enzymes.
Not available
S-EPMC3749516 | biostudies-literature
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