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ProteomicsNEDDylation promotes nuclear protein aggregation and protects the Ubiquitin Proteasome System upon proteotoxic stress
SILAC quantitative mass spectrometry analysis on protein aggregates induced upon heat shock. Two separate performed analysis: A) control siRNA cells (light) with siRNA NEDD8 cells (heavy) and B) control cells (light) with MLN4924 treated cells (heavy). In all conditions cells were heat shocked at 43...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-07-17 | MSV000082623 | MassIVE
ModelsProctor2007 - Age related decline of proteolysis, ubiquitin-proteome system
Proctor2007 - Age related decline of proteolysis, ubiquitin-proteome system This is a stochastic model of the ubiquitin-proteasome system for a generic pool of native proteins (NatP), which have a half-life of about 10 hours under normal conditions. It is assumed that these ...
2024-09-02 | BIOMD0000000105 | BioModels
ProteomicsDiacetyl vapor exposure promotes ubiquitin proteasome stress and precedes bronchiolitis obliterans
Proteomic data from human airway epithelial cells treated with PBS and diacetyl vapor for two consecutive days. Samples were digested with trypsin, then analyzed by LC-MS/MS. Data was searched with MaxQuant.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-02-15 | MSV000086874 | MassIVE
GenomicsUbiquitin-Proteasome System Dysregulation in Alzheimer's Disease Impacts Protein Abundance
Ubiquitin-Proteasome System Dysregulation in Alzheimer's Disease Impacts Protein Abundance
PRJNA1449257 | ENA
UnknownActivation of the ubiquitin-proteasome system contributes to oculopharyngeal muscular dystrophy through muscle atrophy.
Not available
S-EPMC8791501 | biostudies-literature
TranscriptomicsTranscription profiling of rat liver and adipose tissues after 24 h-fasting
The functional balance between brown adipose tissue (BAT) and white adipose tissue (WAT) is important for metabolic homeostasis. We compared the effects of fasting on the gene expression profiles in BAT, WAT and liver, using DNA microarray analysis. Tissues were obtained from rats that had been fe...
ORGANISM(S): Rattus norvegicus 
2008-06-15 | E-GEOD-7623 | biostudies-arrayexpress
TranscriptomicsThe FoxO signature in protein breakdown
Under stress conditions mammalian cells activate compensatory mechanisms to survive and maintain cellular function. During catabolic conditions, such as low nutrients, systemic inflammation, cancer or infections, protein breakdown is enhanced and aminoacids are released from muscles to sustain liver...
ORGANISM(S): Mus musculus 
2015-04-24 | E-GEOD-52667 | biostudies-arrayexpress
ProteomicsNovel functions of the ubiquitin-independent proteasome system in regulating Xenopus germline development
In most species, early germline development occurs in the absence of transcription with germline determinants subject to complex translational and post-translational regulations. Here, we report for the first time that early germline development is influenced by dynamic regulation of the proteasome ...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2019-04-10 | PXD013446 | Pride
Germline development Dnd1 Xenopus Oocyte-to-embryo transition Ubiquitin-independent proteasome 
ProteomicsDeubiquitinating enzymes and the proteasome regulate unique sets of ubiquitin substrates.
The ubiquitin-proteasome axis has been extensively explored at a system-wide level, but the impact of deubiquitinating enzymes (DUBs) on the ubiquitinome remains largely unknown. Using UbiSite technology and inhibitors, we have compared the contributions of the proteasome and DUBs on the ubiquitinom...
ORGANISM(S): Homo sapiens (Human) 
2022-05-23 | PXD030644 | Pride
Dia The ubiquitin-proteasome system Lc-ms/ms 
ProteomicsBenchmarking In-Cell Proteomics For Profiling Neuroblastoma Cell Differentiation And The Ubiquitin-Proteasome System
The human neuroblastoma SH-SY5Y cell line is a widely utilized model for studying neurodegenerative diseases, owing to its ability to differentiate into cells with a neuron-like phenotype. However, a comprehensive understanding of the cellular and molecular mechanisms underpinning the SH-SY5Y cell d...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-05-02 | MSV000097787 | MassIVE
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