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ProteomicsProteomes of wild-type and ubr4 KO HEK293T cells by label-free mass spectrometry
To identify potential mechanisms underlying the role of UBR4 in cargo trafficking, we used quantitative mass spectrometry to analyze the proteomes of wild-type and ubr4 KO HEK293T cells.
ORGANISM(S): Homo sapiens (Human) 
2022-03-24 | PXD020630 | Pride
Hek293 Ubr4 Lfq 
ProteomicsQuantitative proteomics analysis of UBR4 knockout A549 cell line
UBR4 was identified as a potential oncogene in lung adenocarcinoma (LUAD). In this study, we performed a quantitative proteomics analysis using tandem mass tag (TMT) 6-plex technology in UBR4 knockout A549 cell lines to discover an essential role of UBR4 in tumor growth and metastasis.
ORGANISM(S): Homo sapiens (Human) 
2025-06-03 | PXD051417 | Pride
Human Ubr4 Knockout A549 
ProteomicsDiGly analysis of autoubiquitinated UBR4 (residues 4730-5183)
Human recombinant UBR4 protein, consisting of residues 4730-5183, undergoes in vitro autoubiquitination when incubated with the E2 conjugating enzyme UBE2A and the other reaction components. The autoubiquitinated protein was analysed by mass spectrometry to identify modification sites and the ubiqui...
ORGANISM(S): Homo sapiens (Human) 
2023-11-15 | PXD046899 | Pride
Autoubiquitinated Ubr4 
ProteomicsIdentifying insect cell proteins copurified with wild-type human UBR4/KCMF1/CALM1 complex and different domain deletions
The UBR4/KCMF1/CALM1 complex is an important general protein quality control enzyme which extends ubiquitin chains on pre-ubiquitinated proteins to target them for degradation. We observed by cryogenic electron microscopy that the complex purified recombinantly from insect cells is bound to a potent...
ORGANISM(S): Trichoplusia ni 
2025-09-02 | PXD063485 | Pride
Ubr4 Ubiquitin e3 ligase Kcmf1 Trichoplusia ni High-five insect cell expression 
ProteomicsUBR4 KO analysis with TMT labeling
The impact of NatC and UBR4 on the human proteome (protein abundance). Analysis of HAP1 WT siCtr, HAP1 WT siUBR4, HAP1 NAA30 KO siCtr, and HAP1 NAA30 KO siUBR4 cells.
ORGANISM(S): Homo sapiens (Human) 
2023-09-20 | PXD034410 | Pride
Hap1 ko cells Tmt Ubr4 Lc-ms/ms 
UnknownAberrant UBR4 expressions in Hirschsprung disease patients.
Not available
S-EPMC6907357 | biostudies-literature
GenomicsAntagonistic control of myofiber size and muscle protein quality control by the ubiquitin ligase UBR4 during aging
Antagonistic control of myofiber size and muscle protein quality control by the ubiquitin ligase UBR4 during aging
PRJNA629491 | ENA
TranscriptomicsRNAi Screening for Ubiquitin Ligases that Regulate Myofiber Size Identifies a Key Role for UBR4 in Myofiber Hypertrophy in Drosophila and Mice
Sequencing of RNA isolated from the tibialis anterior muscles of 6 month old C57BL/6J mice that had been injected and electroporated with either a control non-targeting siRNA (NT) or two different UBR4 targeting siRNA sequences (UBR4 siRNA5 and siRNA7) to deplete UBR4. Muscles were harvested 7 days ...
ORGANISM(S): Mus musculus 
2019-03-01 | GSE126922 | GEO
TranscriptomicsAntagonistic control of myofiber size and muscle protein quality control by the ubiquitin ligase UBR4 during aging
Sarcopenia is a degenerative condition that consists in the age-induced atrophy and functional decline of skeletal muscle cells (myofibers). A common hypothesis is that inducing myofiber hypertrophy should also reinstate myofiber contractile function but such model has not been extensively tested. H...
ORGANISM(S): Mus musculus 
2021-01-07 | GSE149637 | GEO
GenomicsRNAi Screening for Ubiquitin Ligases that Regulate Myofiber Size Identifies a Key Role for UBR4 in Myofiber Hypertrophy in Drosophila and Mice
RNAi Screening for Ubiquitin Ligases that Regulate Myofiber Size Identifies a Key Role for UBR4 in Myofiber Hypertrophy in Drosophila and Mice
PRJNA523741 | ENA
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