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ProteomicsThe B Cell Repertoire in Multiple Sclerosis Reveals Molecular Mimicry between EBNA1 and GlialCAM
This data set contains the mass spectrometry raw files for the paper The B Cell Repertoire in Multiple Sclerosis Reveals Molecular Mimicry between EBNA1 and GlialCAM. In multiple sclerosis (MS) intrathecal B lymphocytes are directly involved in inflammation and secrete oligoclonal immunoglobulin. Ho...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-02-11 | MSV000086842 | MassIVE
ProteomicsThe interactome of tau phosphorylated at T217 in Alzheimers disease human brain tissue
Tau phosphorylation and aggregation are pathological features of Alzheimers disease. Tau phosphorylated at threonine 217 (pT217) and threonine 231 (pT231) are early fluid biomarkers of Alzheimers disease, suggesting early involvement in disease. However, little is known about the specific actions of...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-11-11 | MSV000096377 | MassIVE
ProteomicsLocalized Proteomic Differences in Choroid Plexus of Alzheimers Disease and Epilepsy Patients
Alzheimers disease and epilepsy are reciprocally related. Among sporadic AD patients, seizures occur in 10-22 percent, and subclinical epileptiform abnormalities occur in 22-5 percent. Cognitive deficits, with prominent short-term memory impairments, occur in most epilepsy patients. Common neurophys...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-02-27 | MSV000091370 | MassIVE
ProteomicsDAP5 directs a widespread alternate form of cap-dependent mRNA translation initiation using eIF3d for specialized cell functions
Affinity purification of eIF4GII, eIF4GI and DAP5 using a HA tag on the N-terminus of each protein.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-05-25 | MSV000082407 | MassIVE
ProteomicsPhosphorylated Tau Interactome in the Human Alzheimers Disease Brain
Accumulation of phosphorylated tau is a key pathological feature of Alzheimers disease. Phosphorylated tau accumulation causes synaptic impairment, neuronal dysfunction and formation of neurofibrillary tangles. The pathological actions of phosphorylated tau are mediated by surrounding neuronal prote...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-04-17 | MSV000085305 | MassIVE
ProteomicsRaphe and Ventrolateral Medulla Proteomics in Sudden Unexplained Death in Childhood with Febrile Seizure History
Sudden unexplained death in childhood (SUDC) is death of a child 12 months old that is unexplained after autopsy and detailed analyses. Among SUDC cases, 28.8% have febrile seizure (FS) history, versus 2-5% in the general population. SUDC cases share features with sudden unexpected death in epilepsy...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-08-12 | MSV000095576 | MassIVE
ProteomicsComparison of the Amyloid Plaque Proteome in Down Syndrome and Alzheimers Disease
Using unbiased localized proteomics, we analyzed amyloid plaques and adjacent plaque-devoid tissue (non-plaque) from post-mortem paraffin-embedded tissues in three cohorts (n=20/group): Down Syndrome, Early Onset AD, and Late Onset AD. We assessed functional associations using Gene Ontology (GO) enr...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-05-18 | MSV000094800 | MassIVE
ProteomicsThe Behcet's disease risk variant HLA-B51/ ERAP1-Hap10 alters human CD8 T cell immunity
The ERAP1 haplotype Hap10 encodes for a variant allotype of the ER-resident peptide-trimming aminopeptidase ERAP1 with low enzymatic activity resembling functional KO. This haplotype recessively confers the highest risk for Behcet's diseases (BD) currently known, but only in carriers of HLA-B*51, th...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-04-25 | MSV000089312 | MassIVE
ProteomicsEndosomal Chemokine Receptor Signalosomes Regulate Central Mechanisms Underlying Cell Migration
Chemokine receptors are GPCRs that regulate chemotactic migration of a wide variety of cells including immune and cancer cells. Most chemokine receptors harbor molecular properties, which are associated with an ability to stimulate G proteins during b-arrestin-mediated internalization into endosomes...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000090362 | MassIVE
ProteomicsQuantitative phosphoproteomic analysis reveals involvement of PD-1 in multiple T cell functions
The programmed cell death protein 1 (PD-1) pathway is a critical inhibitory checkpoint for T cells, and antibodies blocking PD-1 promote immune-mediated identification and clearance of malignant cells. Despite the success of these antibodies, the majority of patients do not respond to PD-1 blockade ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-01-16 | MSV000084813 | MassIVE
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