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TranscriptomicsPositioning of Necrotic Lobular Intraepithelial Neoplasias within the sequence of breast carcinoma progression
Lobular intraepithelial neoplasia grade 3 (LIN) is a recently recognized variant of intraepithelial lobular neoplasia of the breast composed of either uniform, generally small, cells (classic) with massive lobular distension, pleomorphic cells, signet-ring cells, or any cell type with necrosis. In ...
ORGANISM(S): Homo sapiens 
2010-06-20 | E-GEOD-14803 | biostudies-arrayexpress
TranscriptomicsIdentification of Candidate Genes for Sporadic Amyotrophic Lateral Sclerosis by Array Comparative Genomic Hybridisation
Background: Amyotrophic lateral sclerosis (ALS) is a devastating disorder of the central nervous system that leads to progressive loss of upper and lower motor neurons. Most cases are sporadic and of unknown aetiology. In this study, we screened 71 patients with sporadic ALS for the presence of DNA ...
ORGANISM(S): Homo sapiens 
2008-12-24 | E-GEOD-7950 | biostudies-arrayexpress
TranscriptomicsScreening for chromosomal aberrations by array CGH in 74 patients with congenital hypothyroidism
Congenital Hypothyroidism occurs in 1:3500 live births and is therefore the most common congenital endocrine disorder. A spectrum of defective thyroid morphology, termed thyroid dysgenesis, represents 80% of permanent CH cases. Although several candidate genes have been implicated in thyroid develop...
ORGANISM(S): Homo sapiens 
2010-05-31 | E-GEOD-18152 | biostudies-arrayexpress
TranscriptomicsDistribution of segmental duplications in the context of higher order chromatin organisation of human chromosome 7
Background Segmental duplications (SDs) are not evenly distributed along chromosomes. The reasons for this biased susceptibility to SD insertion are poorly understood. Accumulation of SDs is associated with increased genomic instability, which can lead to structural variants and genomic disorders su...
ORGANISM(S): Homo sapiens 
2014-07-01 | E-GEOD-41356 | biostudies-arrayexpress
TranscriptomicsMapping translocation breakpoints by next-generation sequencing
Balanced chromosome rearrangements (BCRs) can cause genetic diseases by disrupting or inactivating specific genes, and the characterisation of breakpoints in disease-associated BCRs has been instrumental in the molecular elucidation of a wide variety of genetic disorders. However, mapping chromosome...
ORGANISM(S): Homo sapiens 
2010-05-22 | E-GEOD-10115 | biostudies-arrayexpress
TranscriptomicsArray comparative genomic hybridization analysis of flat epithelial atypia (DIN1a) and lobular intraepithelial neoplasia
Low grade flat ductal intraepithelial neoplasia (DIN1a, flat epithelial atypia) is one of the earliest morphologically recognizable neoplastic lesions of the breast. Frequently, it occurs in association with lobular intraepithelial neoplasia (LIN). The aim of this study was to elucidate chromosomal ...
ORGANISM(S): Homo sapiens 
2010-05-05 | E-GEOD-18187 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization suggests a role for NRXN1 and APBA2 in schizophrenia
Copy number variations (CNVs) account for a substantial proportion of human genomic variation, and have been shown to cause neurodevelopmental disorders. We sought to determine the relevance of CNVs to the aetiology of schizophrenia. Whole genome, high resolution, tiling path BAC array comparative g...
ORGANISM(S): Homo sapiens 
2008-12-24 | E-GEOD-8606 | biostudies-arrayexpress
TranscriptomicsGenotyping by array of human neuroblastoma cell lines showing MYCN amplification as double minutes or homogeneously staining regions
SNP array profile of cell lines from solid tumors showing MYCN amplification as Double minutes (dmin) and homogeneously staining regions (hsr)
ORGANISM(S): Homo sapiens 
2010-05-25 | E-MEXP-2735 | biostudies-arrayexpress
TranscriptomicsAcute high dose X-irradiation-induced genomic changes in a lung tumor cell line
Accidents with ionizing radiation (IR) often involve acute high dose exposures that can lead to acute radiation syndrome and late effects. IR can induce genomic lesions, cell death or carcinogenesis. Here, we investigated acute IR-induced cellular genomic signatures at the genome wide level. After e...
ORGANISM(S): Homo sapiens 
2011-02-04 | E-GEOD-24876 | biostudies-arrayexpress
UnknownEffect of Angiotensin-Converting Enzyme Inhibitor and Angiotensin Receptor Blocker Initiation on Organ Support-Free Days in Patients Hospitalized With COVID-19: A Randomized Clinical Trial.
Not available
S-EPMC10326520 | biostudies-literature
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