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TranscriptomicsTranscriptional changes in demyelinating canine distemper virus encephalitis
Canine distemper virus (CDV)-induced demyelinating leukoencephalitis (CDV-DL) in dogs is a translational animal model for human demyelinating diseases such as multiple sclerosis. The aim of this study was to perform an assumption-free microarray analysis of gene expression in different subgroups of ...
ORGANISM(S): Canis familiaris 
2014-04-23 | E-MEXP-3917 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse spinal cord from mock-infected and Theilers murine encephalomyelitis (TME)-virus infected animals - time series
Theiler’s murine encephalomyelitis (TME) is an experimentally virus-induced demyelinating leukomyelitis, displaying clinical and pathological similarities to chronic progressive multiple sclerosis.
The aim of this study was to identify pathways associated with demyelination using an assumption-f...
ORGANISM(S): Mus musculus 
2009-06-19 | E-MEXP-1717 | biostudies-arrayexpress
TranscriptomicsMicroarray of non-polarized and M1- and M2-polarized canine macrophages in vitro
Unstimulated (M0), M1-polarized (GM-CSF, LPS, IFNγ-stimulated), and M2-polarized (M-CSF, IL-4-stimulated) canine blood-derived macrophages were generated in vitro and investigated for differences in their transcriptome to create a basis for future investigations upon the role of macrophage polariza...
ORGANISM(S): Canis lupus familiaris 
2017-08-10 | E-MTAB-5458 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling predicts overwhelming homology of Schwann cells, olfactory ensheating cells and Schwann cell-like glia
The objective of this study was to compare the transcriptomes of uninfected and canine distemper virus-infected Schwann cells, olfactory ensheating cells, central nervous system Schwann cell-like glia, and fibroblasts cultured under identical conditions in vitro.
ORGANISM(S): Canis familiaris 
2014-06-02 | E-MTAB-2061 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in isogenic p53wt/p53ko Burkitt lymphoma cell line Seraphine after shRNA-mediated knock-down of p53 pathway members
We performed an shRNA-based RNAi interference screen targeting around 5,000 genes in eight Burkitt lymphoma cell lines. MDM4 and CDKN3 were essential genes in four p53 wild-type Burkitt lymphoma cell lines, but not in four p53 mutant cell lines. To investigate the effect of the gene knock-down on ce...
ORGANISM(S): Homo sapiens 
2019-08-01 | E-MTAB-7134 | biostudies-arrayexpress
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