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ProteomicsOn the utility of ultrafast MS1-only proteomics in drug target discovery studies based on thermal proteome profiling method
Advances in high-throughput high-resolution mass spectrometry and the development of thermal proteome profiling approach (TPP) have made it possible to accelerate a drug target search. Since its introduction in 2014, TPP quickly became a method of choice in chemical proteomics for identifying drug-t...
ORGANISM(S): Homo sapiens (Human) 
2024-10-07 | PXD051712 | Pride
Ultra-short gradient hplc-ms Thermal proteome profiling Drug targets Chemical proteomics 
ProteomicsMultiomics assessment in Enchytraeus crypticus exposed to Ag (nano)materials (Ag NM300K and AgNO 3 )
Silver nanomaterials (AgNMs) are broadly used in many products and also rate among the most studied nanoscaled materials. Their ecotoxicological impact in soil invertebrates has been covered, mostly using standard testing, where endpoints like survival and reproduction are assessed. The underlying m...
ORGANISM(S): Enchytraeus crypticus 
2021-09-10 | PXD024444 | Pride
Nanomaterial Lc-ms/ms E. crypticus Ag Ecotoxicology 
MetabolomicsDetermination and comparison of SCFAs in serum and colon content samples: Alzheimer's disease rat as a case study (SCFA serum and colon content determination)

SCFAs are the main microbial fermentation products from dietary fibers in colon and play a key role in keeping healthy in the whole-body. However, differences of SCFAs concentration in the serum and colon samples collected from rats had attracted few attentions. Here, we optimized the extract and...

2020-11-24 | MTBLS2088 | MetaboLights
MetabolomicsDetermination and comparison of SCFAs in serum and colon content samples: Alzheimer's disease rat as a case study (Method validation)

SCFAs are the main microbial fermentation products from dietary fibers in colon and play a key role in keeping healthy in the whole-body. However, differences of SCFAs concentration in the serum and colon samples collected from rats had attracted few attentions. Here, we optimized the extract and...

2020-11-24 | MTBLS2146 | MetaboLights
MetabolomicsInhibition of anaerobic digestion by various ammonia sources resulted in subtle differences in metabolite dynamics

The impact of ammonia on anaerobic digestion performance and microbial dynamics has been extensively studied, but the concurrent effect of anions brought by ammonium salt should not be neglected. This paper studied this effect using metabolomics and a time-course statistical framework. Metabolomi...

2024-03-01 | MTBLS7859 | MetaboLights
ProteomicsData Set2: Extensive Rewiring of the EGFR Network in Colorectal Cancer Cells Expressing Transforming Levels of KRASG13D
RAW files of corresponding Baits used in Extensive Rewiring of the EGFR Network in Colorectal Cancer Cells Expressing Transforming Levels of KRASG13D
ORGANISM(S): Homo sapiens (Human) 
2019-12-03 | PXD016461 | Pride
Egfr pathway Interactomic Silac Proteins network Hke-3 Hct-116 
ProteomicsExtensive Rewiring of the EGFR Network in Colorectal Cancer Cells Expressing Transforming Levels of KRASG13D
RAW files of corresponding Baits used in Extensive Rewiring of the EGFR Network in Colorectal Cancer Cells Expressing Transforming Levels of KRASG13D
ORGANISM(S): Homo sapiens (Human) 
2019-12-02 | PXD016505 | Pride
Egfr pathway Ap-ms Interactomic Silac Proteins network Hke-3 Hct-116 
Proteomics: Extensive Rewiring of the EGFR Network in Colorectal Cancer Cells Expressing Transforming Levels of KRASG13D
RAW files of corresponding Baits used in Extensive Rewiring of the EGFR Network in Colorectal Cancer Cells Expressing Transforming Levels of KRASG13D
ORGANISM(S): Homo sapiens (Human) 
2019-12-03 | PXD016512 | Pride
Egfr pathway Ap-ms Interactomic Silac Proteins network Hke-3 Hct-116 
ProteomicsData Set3: Extensive Rewiring of the EGFR Network in Colorectal Cancer Cells Expressing Transforming Levels of KRASG13D
RAW files of corresponding Baits used in Extensive Rewiring of the EGFR Network in Colorectal Cancer Cells Expressing Transforming Levels of KRASG13D
ORGANISM(S): Homo sapiens (Human) 
2019-12-02 | PXD016462 | Pride
Egfr pathway Ap-ms Interactomic Silac Proteins network Hke-3 Hct-116 
ProteomicsExtensive Rewiring of the EGFR Network in Colorectal Cancer Cells Expressing Transforming Levels of KRASG13D
RAW files of corresponding Baits used in Extensive Rewiring of the EGFR Network in Colorectal Cancer Cells Expressing Transforming Levels of KRASG13D
ORGANISM(S): Homo sapiens (Human) 
2019-12-02 | PXD016465 | Pride
Egfr pathway Ap-ms Interactomic Silac Proteins network Hke-3 Hct-116 
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