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ProteomicsmTORC1 regulates GRASP55-dependent unconventional secretion in response to stress
In cells, several cargoes are delivered to the cell surface or the extracellular space via unconventional secretion routes. GRASP55 is a Golgi protein that regulates unconventional secretion of distinct proteins and controls the assembly and membrane stacking of Golgi cisternae. Recent work suggeste...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020331 | Pride
Grasp55 Golgi Cellular stress response Mtorc1 Tsc2 Unconventional secretion Rapamycin 
GenomicsInvestigation of conventional and unconventional protein secretion using galectin-3
Investigation of conventional and unconventional protein secretion using galectin-3
PRJNA663090 | ENA
ProteomicsReactive oxygen species (ROS) production activates unconventional secretion of antioxidant proteins
Signal-sequence-lacking superoxide dismutase 1 (SOD1) is secreted upon nutrient starvation, but the physiological relevance of this secretion is unclear. We now report that secreted SOD1 is functionally active. In addition, a secretome analysis has revealed number of other secreted cytoplasmic antio...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-05-14 | PXD010849 | Pride
Unconventional secretion Ros Antioxidant 
GenomicsPlekhg5 regulates the unconventional secretion of Sod1 by presynaptic secretory autophagy
Plekhg5 regulates the unconventional secretion of Sod1 by presynaptic secretory autophagy
PRJNA1122581 | ENA
ProteomicsLiving cell surface proteome - Tracing putative trafficking of the glycolytic enzyme enolase via SNARE-driven unconventional secretion
Living cell surface proteome - Tracing putative trafficking of the glycolytic enzyme enolase via SNARE-driven unconventional secretion
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2012-07-20 | PRD000729 | Pride
OtherInvestigation of conventional and unconventional protein secretion using galectin-3
Protein secretion is an essential process in cell biology. The conventional secretion pathway is well known, and involves proteins with a signal sequence being directed into the endoplasmic reticulum. Once in the lumen of the endoplasmic reticulum, proteins are trafficked through the Golgi and remai...
ORGANISM(S): Homo sapiens 
2020-09-13 | GSE157864 | GEO
TranscriptomicsTranscrioptome analysis of human primary macrophages stimulated by bacterial endotoxin lipopolysaccharide (LPS), and (1,3)-b-glucans, curdlan and glucan from bakerM-BM-4s yeast (GBY)
We performed gene expression microarray experiments to compare the global transcriptional response induced by b-glucans and LPS with their secretomes. We identified 1683, 767 and 1447 genes with over two-fold increase or decrease in LPS-, curdlan- or GBY-stimulated macrophages, respectively. We show...
ORGANISM(S): Homo sapiens 
2014-05-15 | E-GEOD-32282 | biostudies-arrayexpress
GenomicsMycosarcoma maydis
WGS of Ustilago maydis mutant impaired in unconventional secretion
PRJNA634537 | ENA
ProteomicsA noncanonical function of SKP1 regulates the switch between autophagy and unconventional secretion
Intracellular degradation of proteins and organelles by the autophagy-lysosome system is essential for cellular quality control and energy homeostasis. Besides degradation, endolysosomal organelles can fuse with the plasma membrane and contribute to unconventional secretion. Here, we identify a func...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-07-06 | MSV000092361 | MassIVE
TranscriptomicsPlekhg5 regulates the unconventional secretion of Sod1 by presynaptic secretory autophagy
Increasing evidence suggests an essential function for autophagy in unconventional protein secretion (UPS). However, despite its relevance for the secretion of aggregate-prone proteins, the mechanisms of secretory autophagy in neurons have remained elusive. Here we show that the lower motoneuron dis...
ORGANISM(S): Mus musculus 
2024-08-28 | GSE269588 | GEO
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