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MetabolomicsTargeted Sphingolipid analysis of HeLa knockout for expression of GRASP55
Not available
ORGANISM(S): Homo sapiens 
ST001877 | MetabolomicsWorkbench
ProteomicsmTORC1 regulates GRASP55-dependent unconventional secretion in response to stress
In cells, several cargoes are delivered to the cell surface or the extracellular space via unconventional secretion routes. GRASP55 is a Golgi protein that regulates unconventional secretion of distinct proteins and controls the assembly and membrane stacking of Golgi cisternae. Recent work suggeste...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020331 | Pride
Grasp55 Golgi Cellular stress response Mtorc1 Tsc2 Unconventional secretion Rapamycin 
ProteomicsThe Golgi stacking protein GRASP55 represents an effector protein of the natural compound Prodigiosin
The bacterial secondary metabolite prodigiosin has been shown to exert anticancer, antimalarial, antibacterial and immunomodulatory properties. With regard to cancer, it has been reported that it affects tumor cells but not non-malignant cells, making it a promising lead compound for anticancer drug...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD042909 | Pride
Prodigiosin  golgi apparatus  natural compound  autophagy  target identification  secretome 
GenomicsImportance of Golgi homeostasis in hair quality: Grasp55 is crucial for cuticle formation
Importance of Golgi homeostasis in hair quality: Grasp55 is crucial for cuticle formation
PRJNA1335115 | ENA
UnknownGRASP55 regulates Golgi ribbon formation.
Not available
S-EPMC2441664 | biostudies-literature
ProteomicsThe Golgi stacking protein GRASP55 is targeted by the natural compound prodigiosin
The bacterial secondary metabolite prodigiosin has been shown to exert anticancer, antimalarial, antibacterial and immunomodulatory properties. With regard to cancer, it has been reported to affect cancer cells but not non-malignant cells, rendering prodigiosin a promising lead compound for anticanc...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD043247 | Pride
Prodigiosin  golgi apparatus  natural compound  autophagy  target identification 
TranscriptomicsImportance of Golgi homeostasis in hair quality: Grasp55 is crucial for cuticle formation
The Golgi apparatus is a central hub for protein processing, trafficking, and secretion, and its integrity is essential for epidermal barrier function and hair follicle homeostasis. While Golgi dysfunction has been linked to skin and hair abnormalities, its direct contribution to hair shaft formatio...
ORGANISM(S): Homo sapiens 
2026-09-16 | GSE309302 | GEO
UnknownSIRT2 deacetylates GRASP55 to facilitate post-mitotic Golgi assembly.
Not available
S-EPMC6857597 | biostudies-literature
UnknownGRASP55 regulates the unconventional secretion and aggregation of mutant huntingtin.
Not available
S-EPMC9352920 | biostudies-literature
UnknownGRASP55 Senses Glucose Deprivation through O-GlcNAcylation to Promote Autophagosome-Lysosome Fusion.
Not available
S-EPMC8207546 | biostudies-literature
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