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TranscriptomicsUndifferentiated Pleomorphic Sarcoma Model
Analysis of undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma-like tumors from LSL-KrasG12D, p53Fl/Fl mouse model of soft tissue sarcoma. Murine soft tissue sarcomas (n = 17) were compared to normal muscle (n = 4). Tumors were isolated surgically from soft tissue sarcomas generate...
ORGANISM(S): Mus musculus 
2010-03-03 | E-GEOD-16779 | biostudies-arrayexpress
ProteomicsClinicopathologic and Proteomic Characteristics of Low-Grade Undifferentiated Spindle Cell SarcomaClinicopathologic and Proteomic Characteristics of Low-Grade Undifferentiated Spindle Cell Sarcoma
We collected 14 low-grade paired Undifferentiated spindle cell sarcoma (USCS) to conduct a comprehensive mass spectrometry (MS) proteomic analysis on USCSs, while also comparing the clinicopathologic characteristics of low-grade USCSs and UPSs. More than 5600 proteins could be identified. Low-grade ...
ORGANISM(S): Homo sapiens (Human) 
2025-06-28 | PXD061644 | Pride
Undifferentiated spindle sarcoma Pathology Diagnosis Soft tissue tumor Molecular diagnosis Proteomic characteristic Biomarker 
TranscriptomicsMouse Models of Alveolar/Embryonal Rhabdomyosarcoma & Spindle Cell Sarcomas
A series of conditional mouse models of embryonal rhabdomyosarcoma, alveolar rhabdomyosarcoma and spindle cell sarcoma were generated and validated for relavence to corresponding human cancers. Conditional mouse models of embryonal rhabdomyosarcoma, alveolar rhabdomyosarcoma and spindle cell sarcoma...
ORGANISM(S): Mus musculus 
2011-02-17 | E-GEOD-22520 | biostudies-arrayexpress
TranscriptomicsShared prognostic markers in undifferentiated pleomorphic sarcoma and leiomyosarcoma of the extremities
Soft tissue sarcoma diagnostics and prognostics are challenging, particularly in highly malignant and pleomorphic subtypes such as undifferentiated pleomorphic sarcoma (UPS) and leiomyosarcoma (LMS). We applied 32K BAC-arrays and gene expression profiling to 18 extremity soft tissue LMS and 31 extre...
ORGANISM(S): Homo sapiens 
2010-10-08 | E-GEOD-13775 | biostudies-arrayexpress
ProteomicsDiscovery-Based Protein Expression Profiling Identifies Distinct Subgroups and Pathways in Leiomyosarcomas
20 tumor samples run in duplicates, consisting of pleomorphic sarcomas; classfied as leiomyosarcoma or high-grade undifferentiated pleomorphic sarcoma.
ORGANISM(S): Homo sapiens (Human) 
2020-01-27 | PXD000616 | Pride
Sarcoma human label-free 
GenomicsGermline SDHB-inactivating mutation in gastric spindle cell sarcoma (HIPO-021)
Gastrointestinal stromal tumors (GISTs) are the most frequent mesenchymal tumors of the gastrointestinal tract. Inactivating mutations or epigenetic deregulation of succinate dehydrogenase complex (SDH) genes are considered defining features of a subset of GIST occurring in the stomach. Based on com...
EGAS00001004277 | EGA
TranscriptomicsTwo genetic pathways in myxoinflammatory fibroblastic sarcoma and morphologically similar lesions
This SuperSeries is composed of the following subset Series: GSE12592: Gene expression analysis of myxoinflammatory fibroblastic sarcoma, and morphologically similar lesions GSE12593: DNA copy number analysis of myxoinflammatory fibroblastic sarcoma, and morphologically similar lesions Refer to in...
ORGANISM(S): Homo sapiens 
2009-01-25 | E-GEOD-12595 | biostudies-arrayexpress
TranscriptomicsProfiling Side Population Cells in Malignant Fibrous Histiocytoma
We are currently studying the mechanisms that confer tumour initiating potential upon SP, and as part of this work, we undertook gene profiling studies comparing expression between SP and non-SP cells, initially focusing on the most common soft tissue sarcoma, malignant fibrous histiocytoma (or MFH)...
ORGANISM(S): Homo sapiens 
2012-01-17 | E-GEOD-32375 | biostudies-arrayexpress
TranscriptomicsMalignant Fibrous Histiocytoma - Pleomorphic Sarcoma, NOS -Gene expression, Histology and clinical course -A pilot study
This study was performed to identify gene expression differences in not otherwise specified soft tissue sarcomas (NOS, malignant fibrous histiocytomas) and correlate them to histological findings and the clinical course. RNA was isolated and differential gene expression was analysed by the microarra...
ORGANISM(S): Homo sapiens 
2011-01-03 | E-GEOD-14325 | biostudies-arrayexpress
TranscriptomicsTrancription profiling of human soft tissue sarcomas: characterization & reclassification of malignant fibrous histiocytoma
In soft tissue sarcomas, diagnosis of malignant fibrous histiocytoma (MFH) has been a very controversial issue, and MFH is now considered to be reclassified into pleomorphic subtypes of other sarcomas. To characterize and reclassify MFH genetically, we analyzed gene expression in 105 samples from te...
ORGANISM(S): Homo sapiens 
2008-11-22 | E-GEOD-6481 | biostudies-arrayexpress
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