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MetabolomicsRibosomal mistranslation leads to silencing of the unfolded protein response and increased mitochondrial biogenesis

Translation fidelity is the limiting factor in the accuracy of gene expression. With an estimated frequency of 10-4, errors in mRNA decoding occur in a mostly stochastic manner. Little is known about the response of higher eukaryotes to chronic loss of ribosomal accuracy as per an increase in the...

2019-09-17 | MTBLS106 | MetaboLights
MetabolomicsLipidomics study for investigating the role of the Unfolded Protein Response In Arabidopsis seed filling

The Unfolded Protein Response (UPR) is a retrograde, ER-to-nucleus, signalling pathway which is conserved across kingdoms. In plants, it contributes to development, reproduction, immunity and tolerance to abiotic stress. This lipidomic dataset was produced from Arabidopsis thaliana mature seeds. ...

2024-12-02 | MTBLS10597 | MetaboLights
TranscriptomicsTranslational profiling in the unfolded protein response
The unfolded protein response (UPR) couples cellular translation rates and gene expression to the protein folding status of the endoplasmic reticulum (ER). Upon activation, the UPR machinery elicits a general suppression of protein synthesis and activation of stress gene expression, which act coordi...
ORGANISM(S): Mus musculus 
2014-08-28 | E-GEOD-53743 | biostudies-arrayexpress
TranscriptomicsThe Toxoplasma unfolded protein response
To characterize the nature of the unfolded protein response in this Toxoplasma, we carried out microarray analyses to measure the changes in the transcriptome and in translational control during ER stress. Total RNA or RNA fractionated into monosomes or polysomes were purified from parasites treated...
ORGANISM(S): Toxoplasma gondii 
2013-05-24 | E-GEOD-43722 | biostudies-arrayexpress
TranscriptomicsUnfolded Protein Response
To dissect the requirements of membrane protein degradation from the ER, we expressed the mouse major histocompatibility complex class I heavy chain H-2K(b) in yeast. Like other proteins degraded from the ER, unassembled H-2K(b) heavy chains are not transported to the Golgi but are degraded in a pro...
ORGANISM(S): Saccharomyces cerevisiae 
2005-08-16 | E-GEOD-3130 | biostudies-arrayexpress
TranscriptomicsUnfolded protein response in wildtype, ire1, gcn4, gcn2
We measured steady-state mRNA levels by microarray hybridization, comparing WT, (delta)ire1, (delta)gcn4, and (delta)gcn2 cells treated with 2 mM DTT for 30 min (by which time the UPR is qualitatively complete) to untreated samples of the same genotype. WT cells were taken as a positive control for ...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-06 | E-GEOD-1688 | biostudies-arrayexpress
TranscriptomicsTranscriptional and post-transcriptional regulation of VEGF by the unfolded protein response
Inadequate extracellular conditions can adversely affect the environment of the ER and impinge on the maturation of nascent proteins. The resultant accumulation of unfolded proteins activates a signal transduction pathway, known as the unfolded protein response, which serves primarily to protect th...
ORGANISM(S): Homo sapiens 
2011-05-13 | E-GEOD-21979 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Pichia pastoris treated with dithiothereitol to induce unfolded protein response
Experiment aims to induce unfolded protein response in Pichia pastoris, set-up was chosen to be comparable results to DTT experiment.
ORGANISM(S): Pichia pastoris 
2008-09-23 | E-MEXP-1615 | biostudies-arrayexpress
TranscriptomicsThe unfolded protein response in fission yeast modulates stability of select mRNAs to maintain protein homeostasis
Homeostatic control mechanisms are essentil to life. One such mechanism, the unfolded protein response (UPR) operates in all eukarytic cells to adjust protein folding capacity of the endoplasmic reticulum (ER) according to need. UPR induction in all eurkarytic cells to date involves Ire1 (kinase/end...
ORGANISM(S): Schizosaccharomyces pombe 
2012-11-21 | E-GEOD-40298 | biostudies-arrayexpress
TranscriptomicsProtective unfolded protein response in human pancreatic beta cells transplanted into mice
Islet transplantation exposes beta cells to mild hyperglycemia and to the abnormal environment of the transplant site. These conditions may affect beta cells and induce the expression of genes involved in beta cell damage. Gene expression profile of human beta cells exposed to mild hyperglycemia by ...
ORGANISM(S): Homo sapiens 
2010-06-08 | E-GEOD-22097 | biostudies-arrayexpress
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