Sort   by:  
 Page size 
TranscriptomicsGene expression analysis of B cell lymphomas from representative IµHABcl6, IµHABcl6 Ung-/- Msh2-/-, and IµHABcl6 Msh2-/- mouse models.
Somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin (Ig) genes are genomic modification events that occur in germinal center (GC) B cells and are initiated through deamination of cytidine to uracil by activation induced cytidine deaminase (AID). Resulting uracil-guani...
ORGANISM(S): Mus musculus 
2015-12-08 | E-GEOD-48304 | biostudies-arrayexpress
TranscriptomicsCITE-seq of 52 matched primary AML samples from diagnosis and relapse
CITE-seq was used to interrogate transcriptomic and surface immunophenotype heterogeneity at diagnosis and relapse. This experiment reveals cell state evolution of AML blasts at two timepoints and provides new therapeutic avenues for targeting surface antigens in AML.
ORGANISM(S): Homo sapiens 
2026-01-12 | E-MTAB-16321 | biostudies-arrayexpress
TranscriptomicsPredicting Ventral Hernia Recurrence Through Genomic Profiling: An Observational Study
Patients with a history of recurrent ventral hernias (n=10) were compared with a control group (n=8) using high-throughput microarrays. Skin and fascia samples (taken away from the site of the ventral hernia) were analyzed from both groups. Our experiments show distinct genetic profiles between the ...
ORGANISM(S): Homo sapiens 
2012-05-31 | E-GEOD-19637 | biostudies-arrayexpress
TranscriptomicsExploring the role of macroH2A1 in transcription regulation in IMR90 primary human lung fibroblasts with RNA-seq and ChIP-seq
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-09-15 | E-GEOD-54847 | biostudies-arrayexpress
TranscriptomicsTranscriptional landscape of Candida parapsilosis
We used next generation sequencing (RNA-seq) to determine the transcriptional profile of C. parapsilosis growing in several conditions including different media, temperatures and oxygen concentrations. We have 37 Samples representing BMW and YPD media, 1% and 21% oxygen, 30 and 37 degree celsius tem...
ORGANISM(S): Candida parapsilosis 
2011-11-30 | E-GEOD-32714 | biostudies-arrayexpress
TranscriptomicsRNA-seq from control and macroH2A1-depleted IMR90 primary human lung fibroblasts
The histone variant macroH2A1 and the poly(ADP-ribose) polymerase PARP-1 both regulate gene transcription by modulating chromatin structure and function. Of the two macroH2A1 splice variants, macroH2A1.1 and macroH2A1.2, the former is often suppressed in cancer and has the unique ability to interact...
ORGANISM(S): Homo sapiens 
2014-09-15 | E-GEOD-54846 | biostudies-arrayexpress
TranscriptomicsGenome-wide binding of Sd and Yki in imaginal discs
The transcription cofactor Yki drives growth and proliferation in part by controlling mitochondrial network formation. To determine if Yki and Sd are directly bound to DNA corresponding to mitochondrial genes, we used chromatin immunoprecipitation and whole genome tiling arrays (ChIP-chip) to identi...
ORGANISM(S): Drosophila melanogaster 
2012-10-03 | E-GEOD-26678 | biostudies-arrayexpress
TranscriptomicsGenome-wide binding of Ubx and Hth in 3rd thoracic imaginal discs
The Hox genes are responsible for generating morphological diversity along the anterior-posterior axis during animal development. The Drosophila Hox gene Ultrabithorax (Ubx), for example, is required for specifying the identity of the third thoracic (T3) segment of the adult, which includes the dors...
ORGANISM(S): Drosophila melanogaster 
2011-01-21 | E-GEOD-26793 | biostudies-arrayexpress
Sort   by:  
 Page size