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ProteomicsIdentification of Unknown Biological Toxin Protein Using Mass Spectrometry: A Case Study on De Novo Sequencing of Ricin
Currently, the genomes of many toxin proteins remain unsequenced. Characterizing these toxin proteins and their active peptide segments is crucial for the development of detoxification agents and for discovering proteins with potential therapeutic applications. Existing methods for identifying and d...
ORGANISM(S): Ricinus communis 
2025-12-01 | PXD061213 | Pride
Unknown biological toxin protein Heuristic denovo protein sequencing Ricin toxin De novo sequencing Mass spectrometry 
TranscriptomicsTranscription profiling of Bordetella bronchiseptica strains 253 and RB50 to investigate adenylate cyclase toxin (ACT) expression
Bordetella bronchiseptica is a gram-negative respiratory pathogen that causes a diverse spectrum of respiratory disease in a wide-range of hosts. We sought to determine if strains of B. bronchiseptica differed in virulence using the mouse model of infection. Mean lethal doses (LD50) of different B. ...
ORGANISM(S): Bordetella bronchiseptica 
2007-10-01 | E-MEXP-1203 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of Bordetella bronchiseptica strains 253 and RB50 to investigate the cya adenylate cyclase toxin (ACT) operon
Bordetella bronchiseptica is a gram-negative respiratory pathogen that causes a diverse spectrum of respiratory disease in a wide-range of hosts. We sought to determine if strains of B. bronchiseptica differed in virulence using the mouse model of infection. Mean lethal doses (LD50) of different B...
ORGANISM(S): Bordetella bronchiseptica 
2007-10-01 | E-MEXP-1205 | biostudies-arrayexpress
TranscriptomicsInterbacterial signaling via Burkholderia contact-dependent growth inhibition proteins
In prokaryotes and eukaryotes, cell-cell communication and recognition of self are critical to coordinate multicellular functions. While kin and kind discrimination are increasingly appreciated to shape naturally occurring microbe populations, the underlying mechanisms that govern these interbacteri...
ORGANISM(S): Burkholderia thailandensis 
2016-08-09 | E-GEOD-83143 | biostudies-arrayexpress
TranscriptomicsDifferential RNA-seq for identifying toxin MazF and MqsR cleavage sites, beginning of transcripts and stationary phase cleavage sites in Escherichia coli (mRNA, rRNA and other ncRNA)
Bacterial toxin-antitoxin systems help bacteria to reduce their metabolism in various stressful conditions and also play a part in generating antibiotic tolerant bacterial subpopulation called persisters. Many toxins of the bacterial toxin-antitoxin systems are ribonucleases. Such toxins have been m...
ORGANISM(S): Escherichia coli K-12 
2016-11-30 | E-MTAB-4204 | biostudies-arrayexpress
UnknownPotential Prepore Trimer Formation by the Bacillus thuringiensis Mosquito-specific Toxin: MOLECULAR INSIGHTS INTO A CRITICAL PREREQUISITE OF MEMBRANE-BOUND MONOMERS.
Not available
S-EPMC4543642 | biostudies-literature
TranscriptomicsAbsolute quantification of protein production reveals principles underlying protein synthesis rates
A quantitative view of cellular functions requires precise measures of the rates of biomolecule production, especially proteins-the direct effectors of biological processes. Here we present a genome-wide approach, based on ribosome profiling, for measuring absolute protein synthesis rates. The resul...
ORGANISM(S): Escherichia coli 
2014-04-24 | E-GEOD-53767 | biostudies-arrayexpress
OtherAn RNA-targeting ADP-ribosyltransferase toxin uncouples mRNA stability from productive translation
mRNA modifications regulate transcript stability and translation efficiency across diverse biological systems, but the consequences of toxin-mediated mRNA modification in bacteria remain poorly understood. RhsP2 was recently identified as an RNA-targeting interbacterial ADP-ribosyltransferase toxin,...
ORGANISM(S): Escherichia coli 
2026-10-08 | GSE346425 | GEO
TranscriptomicsTranscription profiling of rat neonatal ventricular cardiac mycocytes exposed to endothelin-1 and C3 toxin
Effects of C3 toxin on RNA profiles in neonatal rat ventricular cardiac myocytes exposed to endothelin-1 (1 h)
ORGANISM(S): Rattus norvegicus 
2010-05-25 | E-MEXP-1977 | biostudies-arrayexpress
UnknownThe phage abortive infection system, ToxIN, functions as a protein-RNA toxin-antitoxin pair.
Not available
S-EPMC2630095 | biostudies-literature
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